【摘要】：背景冠狀動(dòng)脈粥樣硬化心臟病(簡(jiǎn)稱冠心病)作為嚴(yán)重威脅人類生命健康重大心血管疾病之一,它是動(dòng)脈粥樣硬化發(fā)展引起器官損害的結(jié)果,是全身性疾病的一部分。動(dòng)脈粥樣硬化性疾病的發(fā)生發(fā)展是一個(gè)漫長(zhǎng)的過(guò)程,早期發(fā)現(xiàn)和識(shí)別出無(wú)癥狀的高危人群以及對(duì)亞臨床期血管病變進(jìn)行干預(yù),是延緩和控制心血管事件的根本措施。踝臂指數(shù)(ankle brachial index,ABI)被作為評(píng)估動(dòng)脈硬化程度的指標(biāo),正發(fā)揮越來(lái)越重的作用。C反應(yīng)蛋白(CRP)是體現(xiàn)炎癥活動(dòng)以及存在的一個(gè)重要指標(biāo)。近年來(lái),研究揭示炎癥可能是啟動(dòng)冠心病動(dòng)脈粥樣硬化過(guò)程的啟動(dòng)因子,而C反應(yīng)蛋白(CRP)直接參與了冠心病的發(fā)生發(fā)展,促進(jìn)粥樣斑塊炎癥反應(yīng)的發(fā)展,是心血管疾病強(qiáng)有力的預(yù)測(cè)因子與危險(xiǎn)因子。目的本研究通過(guò)應(yīng)用冠脈造影(coronary arteriography,CAG)技術(shù)研究ABI、CRP水平與冠狀動(dòng)脈病變程度的關(guān)系,評(píng)價(jià)上述檢測(cè)與冠狀動(dòng)脈病變相關(guān)性,探討其在CHD早期識(shí)別及病變監(jiān)測(cè)中的價(jià)值。方法自2016年2月15日起選取鄭州大學(xué)第一附屬醫(yī)院心內(nèi)科擬診為不穩(wěn)定型心絞痛患者100例,2016年3月29日收集完畢,排除標(biāo)準(zhǔn):風(fēng)濕性瓣膜性心臟病、繼發(fā)性高血壓、急性心肌梗死、外傷、感染、糖尿病、腫瘤、嚴(yán)重的肝腎疾病患者及有可能引發(fā)CRP上升的自身免疫性疾病。所有患者均行CAG。CHD的診斷標(biāo)準(zhǔn)為:至少一支主要冠狀動(dòng)脈血管狹窄50%。根據(jù)造影結(jié)果分為CHD組和非CHD組,且根據(jù)SYNTAX評(píng)分結(jié)果將CHD組分為輕度(1-22分)、中度(23-32分)、重度(≥33分)3組。采用SPSS17.0版本的統(tǒng)計(jì)學(xué)軟件進(jìn)行數(shù)據(jù)的處理。計(jì)數(shù)資料采用百分?jǐn)?shù)或率表示,用卡方檢驗(yàn)。計(jì)量資料用均數(shù)±標(biāo)準(zhǔn)差(x±s)表示,采用獨(dú)立樣本的t檢驗(yàn)。以P0.05為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果1、一般資料分析,各組中,年齡、性別、高血壓、LDL-C、甘油三脂差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。2、與非CHD組比較,CHD組ABI數(shù)值較低,hs-CRP數(shù)值較高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。3、與輕度病變組比較,中、重度病變組ABI數(shù)值較低(P0.05);與中度病變組比較,重度病變組ABI數(shù)值較低(P0.05)。三組間hs-CRP差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論聯(lián)合檢測(cè)ABI和hs-CRP具有重要的實(shí)用價(jià)值,并且是一種簡(jiǎn)易、有效、可以廣泛普及的方法。
[Abstract]:Background as one of the major cardiovascular diseases, coronary atherosclerosis heart disease (CHD) is a serious threat to human life and health. It is the result of organ damage caused by the development of atherosclerosis and a part of systemic disease. The occurrence and development of atherosclerotic diseases is a long process. Early detection and identification of asymptomatic high-risk population and intervention in subclinical vascular diseases are the fundamental measures to delay and control cardiovascular events. The ankle-brachial index (ankle brachial) is used as an index to evaluate the degree of arteriosclerosis. C-reactive protein (CRP) is playing an increasingly important role as an important indicator of inflammatory activity and existence. In recent years, it has been revealed that inflammation may be the promoter of atherosclerosis in coronary heart disease, and C-reactive protein (CRP) is directly involved in the occurrence and development of coronary heart disease and promotes the development of inflammation of atherosclerotic plaque. It is a powerful predictor and risk factor for cardiovascular disease. Objective to study the relationship between the level of coronary arteriography (coronary) and the severity of coronary artery disease, to evaluate the correlation between the above detection and coronary artery disease, and to explore its value in the early identification and monitoring of coronary artery disease (CHD). Methods from February 15, 2016, 100 patients with unstable angina pectoris were selected from the Department of Cardiology, the first affiliated Hospital of Zhengzhou University. The criteria were excluded: rheumatic valvular heart disease and secondary hypertension. Acute myocardial infarction, trauma, infection, diabetes, neoplasms, severe liver and kidney diseases, and autoimmune diseases that may cause an increase in CRP. The diagnostic criteria for CAG.CHD in all patients were at least 50% stenosis of the main coronary artery. According to the results of angiography, the patients were divided into CHD group and non-CHD group. According to the SYNTAX score, the CHD group was divided into three groups: mild (1-22), moderate (23-32) and severe (鈮，

本文編號(hào)：2175393