踝臂指數(shù)、C反應蛋白與冠狀動脈病變程度的探討
發(fā)布時間：2018-08-10 07:32
【摘要】：背景冠狀動脈粥樣硬化心臟病(簡稱冠心病)作為嚴重威脅人類生命健康重大心血管疾病之一,它是動脈粥樣硬化發(fā)展引起器官損害的結(jié)果,是全身性疾病的一部分。動脈粥樣硬化性疾病的發(fā)生發(fā)展是一個漫長的過程,早期發(fā)現(xiàn)和識別出無癥狀的高危人群以及對亞臨床期血管病變進行干預,是延緩和控制心血管事件的根本措施。踝臂指數(shù)(ankle brachial index,ABI)被作為評估動脈硬化程度的指標,正發(fā)揮越來越重的作用。C反應蛋白(CRP)是體現(xiàn)炎癥活動以及存在的一個重要指標。近年來,研究揭示炎癥可能是啟動冠心病動脈粥樣硬化過程的啟動因子,而C反應蛋白(CRP)直接參與了冠心病的發(fā)生發(fā)展,促進粥樣斑塊炎癥反應的發(fā)展,是心血管疾病強有力的預測因子與危險因子。目的本研究通過應用冠脈造影(coronary arteriography,CAG)技術(shù)研究ABI、CRP水平與冠狀動脈病變程度的關系,評價上述檢測與冠狀動脈病變相關性,探討其在CHD早期識別及病變監(jiān)測中的價值。方法自2016年2月15日起選取鄭州大學第一附屬醫(yī)院心內(nèi)科擬診為不穩(wěn)定型心絞痛患者100例,2016年3月29日收集完畢,排除標準:風濕性瓣膜性心臟病、繼發(fā)性高血壓、急性心肌梗死、外傷、感染、糖尿病、腫瘤、嚴重的肝腎疾病患者及有可能引發(fā)CRP上升的自身免疫性疾病。所有患者均行CAG。CHD的診斷標準為:至少一支主要冠狀動脈血管狹窄50%。根據(jù)造影結(jié)果分為CHD組和非CHD組,且根據(jù)SYNTAX評分結(jié)果將CHD組分為輕度(1-22分)、中度(23-32分)、重度(≥33分)3組。采用SPSS17.0版本的統(tǒng)計學軟件進行數(shù)據(jù)的處理。計數(shù)資料采用百分數(shù)或率表示,用卡方檢驗。計量資料用均數(shù)±標準差(x±s)表示,采用獨立樣本的t檢驗。以P0.05為差異有統(tǒng)計學意義。結(jié)果1、一般資料分析,各組中,年齡、性別、高血壓、LDL-C、甘油三脂差異無統(tǒng)計學意義(P0.05)。2、與非CHD組比較,CHD組ABI數(shù)值較低,hs-CRP數(shù)值較高,差異有統(tǒng)計學意義(P0.05)。3、與輕度病變組比較,中、重度病變組ABI數(shù)值較低(P0.05);與中度病變組比較,重度病變組ABI數(shù)值較低(P0.05)。三組間hs-CRP差異無統(tǒng)計學意義(P0.05)。結(jié)論聯(lián)合檢測ABI和hs-CRP具有重要的實用價值,并且是一種簡易、有效、可以廣泛普及的方法。
[Abstract]:Background as one of the major cardiovascular diseases, coronary atherosclerosis heart disease (CHD) is a serious threat to human life and health. It is the result of organ damage caused by the development of atherosclerosis and a part of systemic disease. The occurrence and development of atherosclerotic diseases is a long process. Early detection and identification of asymptomatic high-risk population and intervention in subclinical vascular diseases are the fundamental measures to delay and control cardiovascular events. The ankle-brachial index (ankle brachial) is used as an index to evaluate the degree of arteriosclerosis. C-reactive protein (CRP) is playing an increasingly important role as an important indicator of inflammatory activity and existence. In recent years, it has been revealed that inflammation may be the promoter of atherosclerosis in coronary heart disease, and C-reactive protein (CRP) is directly involved in the occurrence and development of coronary heart disease and promotes the development of inflammation of atherosclerotic plaque. It is a powerful predictor and risk factor for cardiovascular disease. Objective to study the relationship between the level of coronary arteriography (coronary) and the severity of coronary artery disease, to evaluate the correlation between the above detection and coronary artery disease, and to explore its value in the early identification and monitoring of coronary artery disease (CHD). Methods from February 15, 2016, 100 patients with unstable angina pectoris were selected from the Department of Cardiology, the first affiliated Hospital of Zhengzhou University. The criteria were excluded: rheumatic valvular heart disease and secondary hypertension. Acute myocardial infarction, trauma, infection, diabetes, neoplasms, severe liver and kidney diseases, and autoimmune diseases that may cause an increase in CRP. The diagnostic criteria for CAG.CHD in all patients were at least 50% stenosis of the main coronary artery. According to the results of angiography, the patients were divided into CHD group and non-CHD group. According to the SYNTAX score, the CHD group was divided into three groups: mild (1-22), moderate (23-32) and severe (鈮，
本文編號：2175393
[Abstract]:Background as one of the major cardiovascular diseases, coronary atherosclerosis heart disease (CHD) is a serious threat to human life and health. It is the result of organ damage caused by the development of atherosclerosis and a part of systemic disease. The occurrence and development of atherosclerotic diseases is a long process. Early detection and identification of asymptomatic high-risk population and intervention in subclinical vascular diseases are the fundamental measures to delay and control cardiovascular events. The ankle-brachial index (ankle brachial) is used as an index to evaluate the degree of arteriosclerosis. C-reactive protein (CRP) is playing an increasingly important role as an important indicator of inflammatory activity and existence. In recent years, it has been revealed that inflammation may be the promoter of atherosclerosis in coronary heart disease, and C-reactive protein (CRP) is directly involved in the occurrence and development of coronary heart disease and promotes the development of inflammation of atherosclerotic plaque. It is a powerful predictor and risk factor for cardiovascular disease. Objective to study the relationship between the level of coronary arteriography (coronary) and the severity of coronary artery disease, to evaluate the correlation between the above detection and coronary artery disease, and to explore its value in the early identification and monitoring of coronary artery disease (CHD). Methods from February 15, 2016, 100 patients with unstable angina pectoris were selected from the Department of Cardiology, the first affiliated Hospital of Zhengzhou University. The criteria were excluded: rheumatic valvular heart disease and secondary hypertension. Acute myocardial infarction, trauma, infection, diabetes, neoplasms, severe liver and kidney diseases, and autoimmune diseases that may cause an increase in CRP. The diagnostic criteria for CAG.CHD in all patients were at least 50% stenosis of the main coronary artery. According to the results of angiography, the patients were divided into CHD group and non-CHD group. According to the SYNTAX score, the CHD group was divided into three groups: mild (1-22), moderate (23-32) and severe (鈮，
本文編號：2175393
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