【摘要】：目的:探討烏頭赤石脂湯對(duì)老年缺血性心肌病伴心力衰竭患者血清腫瘤壞死因子-α(tumor necrosis factor-α,TNF-α),B型鈉尿肽(B-type natriuretic peptide,BNP)及同型半胱氨酸(homocysteine,Hcy)水平的影響。方法:取鄭州市中醫(yī)院治療的缺血性心肌病心力衰竭老年患者94例,按隨機(jī)數(shù)字表法分為治療組和對(duì)照組,對(duì)照組(47例)予以基礎(chǔ)治療,治療組(47例)在基礎(chǔ)治療上聯(lián)用烏頭赤石脂湯治療,觀察并記錄心室重構(gòu)及心功能、血清指標(biāo)、生活質(zhì)量等指標(biāo),同時(shí)觀察臨床療效及不良反應(yīng)。結(jié)果:治療后對(duì)照組治療有效率(74.47%)低于治療組(91.49%)(P0.05);與治療前比較,兩組治療后心室重構(gòu)及心功能、血清指標(biāo)、生活質(zhì)量均發(fā)生變化,治療組治療后左心室舒張末內(nèi)徑(left ventricular end diastolic diameter,LVEDD),左室收縮末期內(nèi)徑(left ventricular end systolic diameter,LVESD)指標(biāo)低于對(duì)照組(P0.05),左心室射血分?jǐn)?shù)(left ventricular ejection fraction,LVEF),每分鐘輸出量(output per minute,CO)指標(biāo)高于對(duì)照組(P0.05),治療組治療后血清BNP,肌鈣蛋白I(Troponin I,c Tn I),高敏C反應(yīng)蛋白(high-sensitivity C-reactive protein,hs-CRP),TNF-α,Hcy水平低于對(duì)照組(P0.05),治療組治療后生活質(zhì)量改善程度優(yōu)于對(duì)照組(P0.05);兩組治療期間無(wú)嚴(yán)重不良反應(yīng)發(fā)生。結(jié)論:采用烏頭赤石脂湯對(duì)老年缺血性心肌病伴心力衰竭療效確切,能降低血清TNF-α,BNP及Hcy水平,提高生活質(zhì)量。
[Abstract]:Objective: to investigate the effect of aconite Chishi decoction on serum tumor necrosis factor 偽 (tumor necrosis factor- 偽 (TNF- 偽) B natriuretic peptide (B-type natriuretic) and homocysteine (homocysteine) in elderly patients with ischemic cardiomyopathy complicated with heart failure. Methods: Ninety-four elderly patients with heart failure of ischemic cardiomyopathy treated by traditional Chinese Medicine Hospital of Zhengzhou City were divided into treatment group and control group according to random digital table method. The control group (47 cases) was treated with basic treatment. The treatment group (47 cases) was treated with Aconitum Chishi decoction on basic treatment. Ventricular remodeling, cardiac function, serum index, quality of life and other indexes were observed and recorded. The clinical efficacy and adverse reactions were also observed. Results: the effective rate of treatment in the control group (74.47%) was lower than that in the treatment group (91.49%) (P0.05). Left ventricular end-diastolic diameter (left ventricular end diastolic), left ventricular end-systolic diameter (left ventricular end systolic diameterus LVESD), left ventricular ejection fraction (left ventricular ejection fractionation) and (output per minute CO (P 0.05) were significantly lower in the treatment group than those in the control group (P 0.05). The left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (left ventricular ejection fractionation) were significantly higher in the treatment group than those in the control group (P0.05). After treatment, the levels of serum BNPs, I (Troponin IPC Tn I), Gao Min C-reactive protein (high-sensitivity C-reactive protein hs-CRP) in the treatment group were lower than those in the control group (P0.05), and the improvement of the quality of life in the treatment group was better than that in the control group (P0.05). Conclusion: Aconitou Chishi decoction is effective in the treatment of elderly ischemic cardiomyopathy with heart failure. It can reduce serum TNF- 偽 -BNP and Hcy levels and improve quality of life.
【作者單位】： 鄭州市中醫(yī)院;河南省中醫(yī)院;
【基金】：河南省教育廳教育科學(xué)“十二五”規(guī)劃課題項(xiàng)目(2013-JKGHA-0004)
【分類號(hào)】：R541.6;R542.2

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