【摘要】：目的采用三維準連續(xù)式動脈自旋標記(3D p CASL)技術定量分析輕中度高血壓患者腦血流動力學變化。方法 58例高血壓患者和34例年齡相匹配的健康志愿者在3.0T MR掃描儀上行全腦3D p CASL掃描�；�3D p CASL序列獲得腦血流(CBF)圖,采用統(tǒng)計參數(shù)圖8提取各腦區(qū)的CBF值,采用手繪法獲取各腦白質區(qū)的CBF值。結果與健康對照組相比,高血壓患者CBF在雙側半卵圓中心(P=0.000,P=0.000)、側腦室旁白質(P=0.001,P=0.002)、胼胝體壓部(P=0.003)、額葉(P=0.003)、頂葉(P=0.014)、枕葉(P=0.002)、顳葉(P=0.006)、延髓(P=0.012)、腦橋(P=0.016)、中腦(P=0.034)、小腦(P=0.000)及灰質(P=0.001)均明顯降低,而在丘腦、蒼白球、殼核及胼胝體膝部的CBF值差異均無統(tǒng)計學意義(P均0.05)。結論 3D p CASL序列在高血壓患者常規(guī)磁共振成像序列陰性時即可探測到血流動力學的變化,這些CBF下降的區(qū)域提示可能增加了高血壓相關腦小血管病發(fā)生的風險。
[Abstract]:Objective to quantitatively analyze the cerebral hemodynamic changes in mild to moderate hypertension patients by three dimensional quasicontinuous arterial spin labeling (3D p CASL). Methods 58 patients with hypertension and 34 age-matched healthy volunteers were examined with 3. 0T Mr scan. The (CBF) map of cerebral blood flow was obtained based on 3D p CASL sequence. The CBF value of each brain area was extracted by statistical parameter figure 8, and the CBF value of white matter area was obtained by hand drawing method. Results compared with the control group, CBF was significantly decreased in bilateral semicircular center (P0. 000), parietal lobe (Pn0. 014), medulla oblongata (P0. 012), pons (P0. 016), midbrain (P0. 034), cerebellum (P0. 000), cerebellum (P0. 003), frontal lobe (Pn0. 003), parietal lobe (Pn0. 014), occipital lobe (P0. 002), temporal lobe (Pn0. 006), medulla oblongata (P0. 012), pons (Pn0.016), midbrain (P0. 034), cerebellum (P0. 000) and gray matter (P0. 001). However, there was no significant difference in CBF values in thalamus, globus pallidus, putamen and genu of corpus callosum (P0. 05). Conclusion Hemodynamic changes can be detected by 3D p CASL sequence when conventional MRI sequences are negative in hypertensive patients. These regions of decreased CBF may increase the risk of hypertension associated small cerebral angiopathy.
【作者單位】： 中國人民解放軍總醫(yī)院放射科;中國人民解放軍總醫(yī)院心內科;
【基金】：國家自然科學基金(81101034)~~
【分類號】：R544.1;R743

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