【摘要】：心血管疾病(CVD)一直是全世界最主要的死因。由于CVD等慢性疾病對(duì)健康的威脅越來(lái)越大,有必要開(kāi)展生活方式干預(yù)項(xiàng)目以控制這些疾病的危險(xiǎn)因素。本研究的目的是評(píng)估美國(guó)的重要慢病干預(yù)項(xiàng)目—HELPS治療型生活方式改變(TLC)項(xiàng)目對(duì)減少CVD危險(xiǎn)因素和其他慢性疾病的有效性。方法:140位大學(xué)教職工參加為期12周的HELPS TLC項(xiàng)目,干預(yù)前后用配對(duì)t檢驗(yàn)對(duì)其體重、BMI、腰圍(WC)、6分鐘步行距離(6MWD)、空腹血脂和血糖進(jìn)行測(cè)定和比較。結(jié)果:干預(yù)后,6MWD顯著增加,總膽固醇(TC)和WC顯著下降。對(duì)"高危"參與者進(jìn)一步分析顯示:BMI(-1.5±0.5,-3.9%)、TC(-22.8±4.0,-9.0%)、LDL(-14.1±4.9,9.3%)和血糖(-6.9±2.2,-6.1%)均顯著下降;男性腰圍(-4.5±0.8,-10%)顯著減小,女性未見(jiàn)顯著改變(-1.5±0.5,-4.0%)。此外,體重的變化與TC(r=0.43)、LDL(r=0.35)和血糖(r=0.44)的變化均顯著相關(guān)。結(jié)論:參加12周的生活方式干預(yù)項(xiàng)目可以使CVD危險(xiǎn)因素減少,特別是在CVD"高危"個(gè)體中。HELPS TLC項(xiàng)目的遠(yuǎn)期效果還待進(jìn)一步深入研究。
[Abstract]:Cardiovascular disease (CVD) has been the leading cause of death in the world. As chronic diseases such as CVD pose a growing threat to health, lifestyle interventions are needed to control the risk factors for these diseases. The purpose of this study was to evaluate the effectiveness of the HELPS Therapeutic lifestyle change (TLC) program in reducing risk factors for CVD and other chronic diseases in the United States. Methods one hundred and forty faculty members participated in the 12-week HELPS TLC program. The body weight, (WC) 6-minute walking distance (6MWD), fasting blood lipid and blood glucose were measured and compared by paired t test before and after intervention. Results: after intervention, 6 MWD significantly increased, total cholesterol (TC) and WC decreased significantly. Further analysis of "high risk" participants showed that TC (-22.8 鹵4.0 鹵9.0%) and blood glucose (-6.9 鹵2.2 鹵-6.1%) were significantly decreased, waist circumference (-4.5 鹵0.8 鹵-10%) and waist circumference (-1.5 鹵0.5 鹵4.5% -4.0%) were significantly decreased in male (-22.8 鹵4.0%) and blood glucose (-6.9 鹵2.2 鹵-6.1%) were significantly decreased in male (-22.8 鹵4.0%), but not in female (-1.5 鹵0.5% -4.0%). In addition, the changes of body weight were significantly correlated with the changes of TC (r = 0.43), LDL (r = 0.35) and blood glucose (r = 0.44). Conclusion: participating in a 12-week lifestyle intervention program can reduce the risk factors of CVD, especially in individuals at high risk of CVD. The long-term effects of the Helps TLC project need to be further studied.
【作者單位】： Wake森林大學(xué)運(yùn)動(dòng)與健康科學(xué)系;中山大學(xué);
【分類號(hào)】：R54

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