【摘要】：目的:探討本實(shí)驗(yàn)中高脂飼料對(duì)血脂的影響及飼料組分的具體作用。方法:將55只巴馬小型豬分為兩組,正常組5只,手術(shù)組50只。正常組予基礎(chǔ)飼料喂飼,手術(shù)組予高脂喂飼,實(shí)驗(yàn)周期為48周。手術(shù)組于第2周行冠狀動(dòng)脈機(jī)械損傷術(shù),各組于第24、28、36、48周分別測(cè)定血脂水平變化。結(jié)果:因手術(shù)組分為模型組和藥物干預(yù)組,故僅對(duì)正常組和模型組進(jìn)行統(tǒng)計(jì),以便觀察高脂喂飼對(duì)血脂的影響。第24、28、36、48周時(shí),模型組TC、TG、LDL-C、ox-LDL水平明顯高于正常組,統(tǒng)計(jì)學(xué)差異顯著(P0.01);模型組HDL-C水平在第24周明顯高于正常組,統(tǒng)計(jì)學(xué)差異顯著(P0.01);隨后逐漸呈下降趨勢(shì)但仍高于正常組,在28、36周時(shí)兩組比較差異有統(tǒng)計(jì)學(xué)意義(P0.01,P0.05),48周時(shí)兩組比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:本實(shí)驗(yàn)采用的高脂飼料能夠在短時(shí)間內(nèi)造成小型豬的高脂血癥,促進(jìn)冠狀動(dòng)脈粥樣硬化的形成。
[Abstract]:Objective: to study the effect of high-fat diet on blood lipid and the specific effect of feed components in this experiment. Methods: 55 Bama miniature pigs were divided into two groups: normal group (n = 5) and operation group (n = 50). The normal group was fed with basic feed and the operation group with high fat. The experimental period was 48 weeks. The patients in the operation group were treated with mechanical coronary artery injury at the 2nd week, and the blood lipid levels were measured in each group at 24 ~ 2836 ~ 48 weeks. Results: the operation group was divided into model group and drug intervention group, so only the normal group and the model group were statistically analyzed in order to observe the effect of hyperlipidemia on blood lipid. The level of LDL-Cnox-LDL in the model group was significantly higher than that in the normal group (P0.01), the HDL-C level in the model group was significantly higher than that in the normal group at the 24th week (P0.01), the level of HDL-C in the model group was significantly higher than that in the normal group (P0.01), and the level of HDL-C in the model group decreased gradually but was still higher than that in the normal group (P0.01). There was no significant difference between the two groups at the 36-week period (P0.01P05) and at the 48th week (P0.05). Conclusion: the high fat diet can cause hyperlipidemia in miniature pigs and promote the formation of coronary atherosclerosis in short time.
【作者單位】： 遼寧中醫(yī)藥大學(xué);遼寧中醫(yī)藥大學(xué)附屬醫(yī)院;
【基金】：國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃(973計(jì)劃)項(xiàng)目(2013CB531704)
【分類號(hào)】：R-332;R543.5

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