本文選題：結(jié)構(gòu)生物學(xué) + ABCA　； 參考：《生物化學(xué)與生物物理進(jìn)展》2017年09期

【摘要】：正三磷酸腺苷結(jié)合盒轉(zhuǎn)運(yùn)體A1(ATP-binding cassette transporter A1,ABCA1)作為介導(dǎo)細(xì)胞內(nèi)脂質(zhì)流出,維持細(xì)胞脂質(zhì)代謝平衡的重要跨膜蛋白,對(duì)動(dòng)脈粥樣硬化(atherosclerosis,AS)的防治具有重要意義[1].近日,清華大學(xué)結(jié)構(gòu)生物學(xué)高精尖創(chuàng)新中心的顏寧教授與龔欣博士組成的研究團(tuán)隊(duì)(Cell,2017,169:1228-1239)采用冷凍電子顯微鏡技術(shù),經(jīng)過(guò)重組人全長(zhǎng)ABCA1蛋白制備、透射電子顯微
[Abstract]:Adenosine triphosphate binding cassette transporter A1 (ATP-binding cassette transporter A1ABCA1) is an important transmembrane protein that mediates intracellular lipid outflow and maintains lipid metabolic balance in cells. It is of great significance for the prevention and treatment of atherosclerosis (as). Recently, the research team (Cell-2017-1691228-1239) composed of Professor Yan Ning and Dr. Gong Xin from the Center for Advanced Innovation in structural Biology of Tsinghua University prepared the recombinant human full-length ABCA1 protein with transmission electron microscopy (TEM) using frozen electron microscopy.
【作者單位】： 南華大學(xué)心血管疾病研究所動(dòng)脈粥樣硬化學(xué)湖南省重點(diǎn)實(shí)驗(yàn)室醫(yī)學(xué)研究實(shí)驗(yàn)中心湖南省分子靶標(biāo)新藥研究協(xié)同創(chuàng)新中心;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(81570408)
【分類號(hào)】：R54
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本文編號(hào)：2101069