本文選題：血管緊張素轉(zhuǎn)化酶基因 + 血管緊張素轉(zhuǎn)化酶Ⅱ基因��； 參考：《中國老年學雜志》2017年16期

【摘要】：目的探討血管緊張素轉(zhuǎn)化酶(ACE)基因和ACE2基因遺傳變異與中國北方漢族人群冠心病(CHD)的關系。方法選擇在吉林大學第一醫(yī)院確診并住院的246例CHD患者和同期進行健康體檢的251例正常人為研究對象,采用聚合酶鏈式反應-限制性片段長度多態(tài)性(PCRRFLP)技術(shù)檢測ACE基因rs4461142位點及ACE2基因rs1514283位點的多態(tài)性并進行統(tǒng)計分析。結(jié)果病例組和對照組高血壓、糖尿病所占的比例具有統(tǒng)計學差異(P0.05);兩組rs4267385位點、rs1514283位點等位基因和基因型頻數(shù)分布無統(tǒng)計學差異(P0.05)。結(jié)論 ACE基因rs4267385位點和ACE2基因rs1514283位點可能不是中國北方漢族人群CHD的易感位點。
[Abstract]:Objective to investigate the relationship between angiotensin converting enzyme (ACE) gene and ACE2 gene genetic variation and coronary heart disease (CHD) in Chinese Han population. Methods 246 CHD patients who were diagnosed and hospitalized in the first Hospital of Jilin University and 251 healthy people who underwent physical examination at the same time were selected as the study subjects. Polymerase chain reaction-restriction fragment length polymorphism (PCR RFLP) was used to detect the polymorphism of ACE gene rs4461142 locus and ACE2 gene rs1514283 locus. Results there was significant difference in the proportion of hypertension and diabetes between the case group and the control group (P0.05), while there was no significant difference in alleles and genotype frequencies of rs1514283 at rs4267385 locus between the two groups (P0.05). Conclusion ACE gene rs4267385 locus and ACE2 gene rs1514283 locus may not be susceptible to CHD in Han population of northern China.
【作者單位】： 吉林大學中日聯(lián)誼醫(yī)院急診科;吉林大學公共衛(wèi)生學院勞動衛(wèi)生與環(huán)境衛(wèi)生學教研室;江西省腫瘤醫(yī)院;
【基金】：教育部高校博士點專項基金(No.20100061110071)
【分類號】：R541.4

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