本文選題：果糖二磷酸鈉 + 急性心肌梗死��； 參考：《中國藥房》2017年08期

【摘要】：目的:探討果糖二磷酸鈉對急性心肌梗死(AMI)患者心功能、心肌損傷標志物、缺血修飾白蛋白(IMA)、和肽素的影響及安全性。方法:采用回顧性研究方法,選擇2014年2月-2015年4月在南陽市第二人民醫(yī)院接受治療的102例AMI患者的臨床資料,按治療方案不同分為觀察組和對照組,各51例。兩組患者均行基礎治療,并給予尿激酶靜脈滴注+肝素靜脈泵注+阿司匹林口服等對癥治療方案。觀察組患者在此基礎上聯(lián)用注射用果糖二磷酸鈉10 g靜脈滴注,bid。兩組患者均連續(xù)治療7~10 d。記錄兩組患者治療前后左室舒張末期內(nèi)徑(LVDd)、左室收縮末期內(nèi)徑(LVSd)、左室射血分數(shù)(LVEF)等心功能指標,心肌肌鈣蛋白Ⅰ(cTnⅠ)、肌酸激酶同工酶(CK-MB)等心肌損傷標志物及IMA、和肽素等指標變化情況,心功能分級情況,以及不良反應和不良事件發(fā)生情況。結(jié)果:治療前,兩組患者上述指標比較,差異均無統(tǒng)計學意義(P0.05)。治療后12、24 h,兩組患者的LVDd、LVSd較治療前顯著縮短,LVEF、IMA水平較治療前顯著升高,CK-MB、和肽素水平較治療前顯著降低,且觀察組患者的改善幅度均顯著大于對照組同期,差異均有統(tǒng)計學意義(P0.05);兩組患者的cTnⅠ水平較治療前逐漸提升[觀察組患者治療后12 h與治療前比較差異無統(tǒng)計學意義(P0.05)],但觀察組患者的增幅顯著小于對照組同期,差異均有統(tǒng)計學意義(P0.05)。治療后24 h,觀察組患者心功能Killip分級的Ⅰ~Ⅱ級率為96.1%,顯著高于對照組的78.4%,差異有統(tǒng)計學意義(P0.05)。兩組患者均未見嚴重的不良反應發(fā)生,不良反應發(fā)生率比較差異無統(tǒng)計學意義(P0.05);在不良事件方面,兩組患者除死亡率比較差異無統(tǒng)計學意義(P0.05)外,觀察組患者發(fā)生嚴重心律失常、再發(fā)心肌梗死、梗死后心絞痛等不良事件的例數(shù)及總發(fā)生率均顯著少于或低于對照組,差異有統(tǒng)計學意義(P0.05)。結(jié)論:在常規(guī)對癥治療基礎上聯(lián)用果糖二磷酸鈉治療AMI,可有效提升心肌損傷標志物、IMA及和肽素水平,改善患者心功能,降低不良事件發(fā)生風險,從而提升預后質(zhì)量。
[Abstract]:Aim: to investigate the effects and safety of fructose diphosphate on cardiac function, myocardial injury markers, ischemia modified albumin IMAN and peptide in acute myocardial infarction (AMI) patients. Methods: the clinical data of 102 AMI patients who were treated in the second people's Hospital of Nanyang City from February 2014 to April 2015 were retrospectively studied. The patients were divided into observation group (51 cases) and control group (51 cases) according to different treatment schemes. The patients in both groups were treated with basic therapy and urokinase intravenous infusion of heparin, aspirin, oral administration and other symptomatic treatments. The patients in the observation group were treated with 10 g fructose diphosphate intravenously. The patients in both groups were treated continuously for 7 to 10 days. Left ventricular end-diastolic diameter (LVDdN), left ventricular end-systolic diameter (LVSdN), left ventricular ejection fraction (LVVEF) and so on were recorded before and after treatment. Cardiac troponin 鈪，

本文編號：2045835