本文選題：亞甲基四氫葉酸還原酶 + 基因多態(tài)性　； 參考：《中國(guó)動(dòng)脈硬化雜志》2017年02期

【摘要】：目的探討血漿同型半胱氨酸(Hcy)及其代謝關(guān)鍵酶亞甲基四氫葉酸還原酶(MTHFR)C677T基因多態(tài)性與中國(guó)漢族人群原發(fā)性高血壓患者血脂異常的關(guān)系。方法選取原發(fā)性高血壓患者312例,女性134例,男性178例,平均年齡58.25歲,收集患者基本資料,檢測(cè)血漿Hcy、血脂、空腹血糖(FBG)、尿酸(UA)等臨床生物化學(xué)指標(biāo)。應(yīng)用Taqman探針技術(shù)檢測(cè)患者M(jìn)THFR C677T基因分型。根據(jù)2007年中國(guó)成人血脂異常防治指南,將入選的312例原發(fā)性高血壓患者分為血脂異常組194例和血脂正常組118例,同時(shí)將血脂異常組分為4個(gè)亞組:高膽固醇血癥組54例,高甘油三酯血癥組53例,混合型高脂血癥組59例,低高密度脂蛋白血癥組22例,并進(jìn)行亞組分析。結(jié)果血脂異常組體質(zhì)指數(shù)(BMI)、FBG、UA高于血脂正常組(P0.01)。血脂異常組MTHFR C677T的CC、CT、TT三種基因型頻率和C、T兩種等位基因頻率與血脂正常組比較差異無統(tǒng)計(jì)學(xué)意義(P0.05),血脂異常各亞組之間的基因型頻率、等位基因頻率差異無統(tǒng)計(jì)學(xué)意義,與血脂正常組之間差異亦無統(tǒng)計(jì)學(xué)意義。MTHFR C677T不同基因型間四項(xiàng)血脂水平均無統(tǒng)計(jì)學(xué)差異,但TT基因型者Hcy水平高于CT、CC基因型者(P0.05),而CT基因型者Hcy水平與CC基因型者比較差異無統(tǒng)計(jì)學(xué)意義(P0.05)。高密度脂蛋白膽固醇(HDLC)水平與Hcy水平呈負(fù)相關(guān)(r=-0.116,P0.05),但是在校正了年齡、BMI、UA、FBG后此相關(guān)性消失;總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白膽固醇(LDLC)水平與Hcy水平無相關(guān)性(P0.05)。Logistic回歸分析顯示,在校正了BMI、FBG、UA后基因型與血脂異常無相關(guān)性(P0.05)。結(jié)論在原發(fā)性高血壓患者中MTHFR C677T基因多態(tài)性與血脂異常無關(guān)聯(lián),而與Hcy呈顯著相關(guān)。血脂異常與FBG、UA、BMI有關(guān),而與Hcy無關(guān),但HDLC與血漿Hcy水平呈負(fù)相關(guān)。
[Abstract]:Objective to investigate the relationship between plasma homocysteine (Hcyn) and methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and dyslipidemia in essential hypertension patients of Han nationality in China. Methods 312 patients with essential hypertension, 134 women and 178 men, with an average age of 58.25 years, were selected. The basic data of the patients were collected and the clinical biochemical indexes such as plasma Hcycy, blood lipid, fasting blood glucose, FBGG and UAA were measured. MTHFR C677T genotyping was detected by Taqman probe technique. According to the guidelines for the prevention and treatment of adult dyslipidemia in China in 2007, 312 patients with essential hypertension were divided into two groups: 194 patients with dyslipidemia and 118 patients with normal blood lipids. At the same time, the dyslipidemia group was divided into four subgroups: 54 patients with hypercholesterolemia. There were 53 cases of hypertriglyceridemia group, 59 cases of mixed hyperlipidemia group and 22 cases of low density lipoproteinemia group. Results the body mass index (BMI) of the dyslipidemia group was higher than that of the normal blood lipid group (P 0.01). There was no significant difference in three genotypes and two alleles between MTHFR C677T and normal blood lipid group (P 0.05), but there was no significant difference in genotype frequency and allele frequency between subgroups with dyslipidemia. There was no significant difference between MTHFR C677T and normal blood lipids. There was no significant difference among the four genotypes of MTHFR C677T. However, the level of Hcy in TT genotype was higher than that in CTN CC genotype, but there was no significant difference in Hcy level between CT genotype and CC genotype. High density lipoprotein cholesterol (HDLC) level and Hcy level were negatively correlated with Hcy, but the correlation disappeared after adjusting for age BMIU UABG, but there was no correlation between total cholesterol TCU, triglyceride TGG, low density lipoprotein cholesterol (LDLCc) level and Hcy level (P0.05n.Logistic regression analysis showed that there was no correlation between HDLC level and Hcy level. There was no correlation between genotype and dyslipidemia after correcting BMIA FBGG UA (P 0.05). Conclusion MTHFR C677T gene polymorphism is not associated with dyslipidemia in patients with essential hypertension, but is significantly correlated with Hcy. Dyslipidemia was associated with BMI, but not with Hcy, but HDLC was negatively correlated with plasma Hcy level.
【作者單位】： 山東中醫(yī)藥大學(xué);山東大學(xué)附屬千佛山醫(yī)院心內(nèi)二科;
【基金】：山東省科技發(fā)展計(jì)劃項(xiàng)目(2014GSF118055) 山東省醫(yī)藥衛(wèi)生科技發(fā)展計(jì)劃項(xiàng)目(2013WS0130)
【分類號(hào)】：R544.1

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本文編號(hào)：2044741