本文選題：冠狀動脈粥樣硬化性心臟病 + 發(fā)病風險或易感性�。� 參考：《中國醫(yī)科大學學報》2017年06期

【摘要】：目的探討中國北方漢族人群髓樣分化因子88(MyD88)基因3’非編碼區(qū)(3’-UTR)rs7744多態(tài)性與冠狀動脈粥樣硬化性心臟病(CAD)發(fā)病風險及嚴重程度的關系。方法收集2013年9月至2015年9月中國醫(yī)科大學附屬第一醫(yī)院血液標本810例。CAD組540例,對照組270例,采用聚合酶鏈反應-限制性片段長度多態(tài)性(PCR-RFLP)技術檢測rs7744多態(tài)性,并收集臨床資料。結果 MyD88基因rs7744符合Hardy-Weiberg平衡(P0.1)。對MyD88基因rs7744多態(tài)性與CAD發(fā)病風險的關系進行總體和分層分析。MyD88基因rs7744多態(tài)位點,年齡50歲,AG突變雜合型攜帶者CAD的發(fā)病風險是AA野生純合型攜帶者的0.38倍(95%CI:0.17~0.93;P=0.029)。對My D88基因rs7744多態(tài)性與CAD嚴重程度的關系進行冠狀動脈病變支數(shù)及改良Gensini評分分析。在改良Gensini評分分析中,My D88基因rs7744多態(tài)位點,GG突變純合型攜帶者的改良Gensini評分顯著低于AA野生純合型攜帶者(5.23±3.85 vs 7.49±4.96;P=0.011)。結論 MyD88基因3’-UTR區(qū)rs7744多態(tài)性與CAD發(fā)病風險及嚴重程度存在關聯(lián)關系。攜帶rs7744突變基因型的年齡50歲人群,CAD的發(fā)病率比較低。rs7744突變基因型攜帶者的改良Gensini評分顯著低于野生型攜帶者。
[Abstract]:Objective to investigate the relationship between the 3'noncoding region of myeloid differentiation factor 88 (MyD88) gene and the risk and severity of coronary atherosclerotic heart disease (CAD). Methods from September 2013 to September 2015, rs7744 polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 810 blood samples from the first affiliated Hospital of China Medical University, 540 cases in the CAD group and 270 cases in the control group. Clinical data were collected. Results MyD88 rs7744 was consistent with Hardy-Weiberg equilibrium P0.1. The relationship between the rs7744 polymorphism of MyD88 gene and the risk of rs7744 was analyzed. The polymorphic loci of MyD88 gene. The age of 50 years old carriers with AG mutation was 0.38 times as high as 95% 95% of wild homozygous carriers. The relationship between rs7744 polymorphism of my D88 gene and severity of CAD was analyzed by coronary artery disease branch number and modified Gensini score. In the modified Gensini score analysis, the modified Gensini score of homozygous carriers with rs7744 polymorphism of my D88 gene was significantly lower than that of carriers with AA wild homozygotes (5.23 鹵3.85 vs 7.49 鹵4.96). Conclusion there is an association between the rs7744 polymorphism in the 3- UTR region of MyD88 gene and the risk and severity of the disease. The incidence of rs7744 in 50 years old people with rs7744 mutation genotype was lower than that in wild type carriers.
【作者單位】： 中國醫(yī)科大學附屬第一醫(yī)院心血管超聲科;中國醫(yī)科大學附屬第一醫(yī)院神經(jīng)外科;
【基金】：遼寧省自然科學基金(2015020506)
【分類號】：R541.4
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本文編號：2032975