本文選題：2型糖尿病 + C肽　； 參考：《皖南醫(yī)學(xué)院》2017年碩士論文

【摘要】：目的:探討血清C肽與2型糖尿病患者頸部血管病變之間的關(guān)系。使用Logistic回歸分析2型糖尿病患者頸部血管病變的危險(xiǎn)因素,采用受試者工作曲線(xiàn)(ROC曲線(xiàn))對(duì)血清C肽診斷2型糖尿病患者頸部血管病變的最佳臨界值進(jìn)行初步探討,進(jìn)行診斷性評(píng)價(jià)。方法:收集住院的2型糖尿病患者203例,對(duì)所有患者進(jìn)行頸部血管彩超檢查,觀察頸動(dòng)脈中膜厚度(IMT),有無(wú)斑塊,記錄患者體重指數(shù)(BMI)、吸煙史、性別、年齡、糖尿病病程,監(jiān)測(cè)空腹血糖(FBG)及餐后2小時(shí)血糖(PBG)、空腹及餐后2小時(shí)C肽、糖化血紅蛋白、低密度脂蛋白、高密度脂蛋白、血清膽固醇、甘油三酯。IMT值1.0毫米為無(wú)頸部血管病變組(對(duì)照組),IMT在≥1.0毫米為頸部血管病變組,比較兩組之間的C肽水平和其他相關(guān)指標(biāo),并用Logistic回歸分析2型糖尿病患者頸部血管病變的危險(xiǎn)因素,最后采用受試者工作曲線(xiàn)(ROC曲線(xiàn))對(duì)血清C肽水平診斷2型糖尿病患者頸部血管病變的最佳臨界值進(jìn)行初步探討,進(jìn)行診斷性評(píng)價(jià)。結(jié)果:1、兩組間各指標(biāo)的比較:頸部血管病變組的空腹C肽、餐后2小時(shí)C肽、高密度脂蛋白均低于對(duì)照組,Hb A1C、糖尿病病程、低密度脂蛋白均高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義。2、Logistic回歸分析顯示,進(jìn)入回歸方程的變量是2型糖尿病病程、空腹C肽、餐后2小時(shí)C肽、低密度脂蛋白、高密度脂蛋白、吸煙、糖化血紅蛋白。3、ROC曲線(xiàn)顯示空腹C肽診斷2型糖尿病合并頸部血管病變最佳臨界值為1.81ng/ml,曲線(xiàn)下面積為0.738,標(biāo)準(zhǔn)差為0.035,可信區(qū)間為0.669~0.806。餐后2小時(shí)C肽識(shí)別和診斷亞臨床的最佳臨界值為5.03ng/ml,曲線(xiàn)下面積為0.777,標(biāo)準(zhǔn)差為0.032,可信區(qū)間為0.714~0.840。結(jié)論:1、2型糖尿病患者合并頸部血管病變時(shí)空腹、餐后2小時(shí)C肽、高密度脂蛋白下降,糖化血紅蛋白、低密度脂蛋白升高。2、2型糖尿病患者合并頸部血管病變的危險(xiǎn)因素有2型糖尿病病程、空腹C肽、餐后2小時(shí)C肽、低密度脂蛋白、高密度脂蛋白、吸煙、糖化血紅蛋白。3、2型糖尿病患者空腹C肽水平低于1.82ng/ml,進(jìn)食后120分鐘C肽低于5.03ng/ml時(shí)發(fā)生頸部血管病變的風(fēng)險(xiǎn)增加。
[Abstract]:Objective: to investigate the relationship between serum C-peptide and cervical vascular lesions in type 2 diabetes mellitus. Logistic regression analysis was used to analyze the risk factors of cervical vascular disease in type 2 diabetic patients. The optimal critical value of serum C-peptide in the diagnosis of cervical vascular disease in type 2 diabetes mellitus was preliminarily studied by using the operating curve of subjects and ROC curve. Diagnostic evaluation was performed. Methods: 203 inpatients with type 2 diabetes mellitus were examined by color Doppler ultrasonography. Carotid intima-media thickness (IMT), plaques, body mass index (BMI), smoking history, sex, age, course of diabetes were recorded. Fasting blood glucose (FBG) and 2 hours postprandial blood glucose (PBGG), fasting and 2 hours postprandial C-peptide, glycosylated hemoglobin, low density lipoprotein, high density lipoprotein, serum cholesterol were monitored. Triglyceride. IMT value was 1.0 mm in non-cervical vascular lesion group (control group 鈮，

本文編號(hào)：2026140