本文選題：民族 + 半乳糖凝集素-3��； 參考：《石河子大學(xué)》2015年碩士論文

【摘要】：目的:了解新疆地區(qū)哈薩克族與漢族慢性心功能不全患者血清中半乳糖凝集素-3(galectin-3)表達水平和心臟結(jié)構(gòu)、功能的變化及差異,探討兩民族心衰患者galectin-3與心臟結(jié)構(gòu)和功能的關(guān)系。方法:選取就診于石河子大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院心內(nèi)科及急診科的患者198人,其中哈薩克族心功能不全患者88例,男47例,女41例,年齡47~86(63.59±11.82)歲,漢族心功能不全患者70例,男39例,女31例,年齡44~89(68.11±10.34)歲,哈薩克族對照組20人,男10例,女10例,年齡45~88(62.11±10.12)歲;漢族對照組20人,男11例,女9例,年齡45~83(66.25±10.32)歲。根據(jù)美國Framingham心衰診斷標(biāo)準(zhǔn)和紐約心臟病協(xié)會(New York Heart Association,NYHA)分級標(biāo)準(zhǔn)對心衰患者進行診斷和分級,采用酶聯(lián)免疫吸附法(ELISA)法測定galectin-3水平,應(yīng)用心臟彩色多普勒超聲檢查心臟結(jié)構(gòu)和功能。采用SPSS17.0統(tǒng)計軟件對結(jié)果進行分析,以P0.05認為有統(tǒng)計學(xué)差異。結(jié)果:(1)哈薩克族與漢族對照組血清中g(shù)alectin-3無明顯差異[(4.66±2.17)vs(4.78±2.06)ng/ml,P0.05];(2)哈薩克族與漢族心功能Ⅰ~Ⅱ級患者血清中g(shù)alectin-3均高于對照組[(8.51±2.51)vs(4.66±2.17)ng/ml,(7.36±2.82)vs(4.78±2.06)ng/ml,P0.05];(3)哈薩克族心功能Ⅰ~Ⅱ級、Ⅲ級、Ⅳ級患者galectin-3水平均高于同級漢族心衰患者[(8.51±2.51)vs(7.36±2.82)ng/ml,(11.62±3.03)vs(9.27±3.96)ng/ml,(14.69±3.04)vs(12.06±3.06)ng/ml,P0.05];(4)哈薩克族心衰組左房內(nèi)徑(LAD)、左室舒張末內(nèi)徑(LVEDD)均較漢族心衰組大[(40.72±5.70)vs(35.23±6.85)mm,50(47 52)vs(47.91±8.42)mm,P0.05],左室射血分數(shù)(LVEF)較漢族心衰組低[59(42 63)vs 62(51 67)%,P0.05];(5)哈薩克族和漢族心衰組galectin-3均與LAD、LVEDD呈正相關(guān),與LVEF呈負相關(guān),且與哈薩克族心衰組相關(guān)性更高[(r1=0.31,P0.01)vs(r2=0.25,P0.05);(r3=0.36,P0.01)vs(r4=0.34,P0.01)(r5=-0.407,P0.01)vs(r6=-0.285,P0.05)]。結(jié)論:(1)無論是哈薩克族還是漢族心功能不全患者血清中Galectin-3的表達均明顯高于各自民族的對照組水平,說明心功能不全時兩民族Galectin-3表達都會升高,Galectin-3可以用于心功能不全的早期診斷。(2)哈薩克族和漢族心功能不全患者Galectin-3的表達水平均隨著NYHA心功能分級的升高而升高,說明隨著心功能不全程度的加劇,Galectin-3的表達也升高,galectin-3可用于心功能不全病情嚴(yán)重程度的評估。(3)哈薩克族與漢族對照族galectin-3表達無明顯異常,而哈薩克族心功能NYHAⅠ~Ⅱ級、Ⅲ級、Ⅳ級均較漢族心功能不全者高,說明galectin-3可用于同民族心衰病情嚴(yán)重程度的評估,對于其他民族的評估無意義。(4)同級哈薩克族心功能不全患者LAD、LVEDD均漢族心功能不全患者高,而LVEF較漢族患者低,說明哈薩克族心功能不全心臟重構(gòu)程度較同級漢族嚴(yán)重,而相關(guān)性分析顯示,無論是哈薩克族還是漢族,galectin-3都與LAD、LVEDD成正相關(guān),與LVEF成負相關(guān),而galectin-3與哈薩克族LAD、LVEDD、LVEF的相關(guān)性更高,說明galectin-3對哈薩克族心功能不全患者心臟重塑嚴(yán)重程度的評估更準(zhǔn)確。
[Abstract]:Objective: To investigate the level of serum galactectin -3 (galectin-3) expression and cardiac structure, function changes and differences in serum of the Kazak and Han patients with chronic heart failure in Xinjiang, and to explore the relationship between galectin-3 and cardiac structure and function in two people with heart failure. Methods: select the first affiliated medicine in Medical College of Shihezi University. There were 198 patients in the hospital department of Cardiology and emergency department, including 88 cases of Kazak heart failure, 47 male and 41 female, age 47~86 (63.59 + 11.82) years, 70 cases of Han heart dysfunction, 39 men, 31 women, age of 68.11 + 10.34 years, Kazak group 20, male 10, female, 45~88, and Han control. Group 20, male 11, female 9, age 45~83 (66.25 + 10.32) years old. According to the standard of Framingham heart failure diagnosis and New York heart disease association (New York Heart Association, NYHA) classification criteria for diagnosis and classification of patients with heart failure, enzyme linked immunosorbent assay (ELISA) method was used to determine the level of galectin-3, color Doppler echocardiography was used. The results were analyzed with SPSS17.0 statistical software, and the results were statistically analyzed with P0.05. Results: (1) there was no significant difference in serum galectin-3 between Kazak and Han control group [(4.66 + 2.17) vs (4.78 + 2.06) ng/ml, P0.05]; (2) the serum galectin-3 of the hassak and Han heart function class I ~ II patients were higher than those of the Han nationality. The control group [(8.51 + 2.51) vs (4.66 + 2.17) ng/ml, (7.36 + 2.82) vs (4.78 + 2.06) ng/ml, P0.05]; (3) the Kazak heart function I ~ II, grade III and grade IV patients were higher than those of the same class Han heart failure patients [8.51 + 2.51) vs (7.36 + 2.82) ng/ml, (11.62 + 2.82) ng/ml, vs + vs ng/ml The left atrial diameter (LAD) and left ventricular end diastolic diameter (LVEDD) in the sack heart failure group were higher than that of the Han heart failure group [(40.72 + 5.70) vs (35.23 + 6.85) mm, 50 (4752) vs (47.91 + 8.42) mm, P0.05], and left ventricular ejection fraction (LVEF) lower [59 (4263) vs 62 (5167)%, P0.05], than the Han heart failure group. (5) the Kazak and Han heart failure groups were both Cheng Zhengxiang Conclusion: (1) the expression of the serum in both Kazak and Han patients with cardiac insufficiency is significantly higher than the control of the LVEF group of the Kazak and the Han people. Group level, indicating that the expression of Galectin-3 in the two ethnic groups increased and Galectin-3 could be used for early diagnosis of cardiac dysfunction. (2) the expression level of Galectin-3 in Kazak and Han patients with cardiac insufficiency increased with the increase of NYHA cardiac function classification, indicating that with the aggravation of cardiac insufficiency, Galectin-3 The expression was also increased, and galectin-3 could be used to evaluate the severity of heart failure. (3) the expression of galectin-3 in Kazak and Han controls had no obvious abnormality, while the Kazak heart function NYHA I ~ II, grade III and IV were higher than those of the Han heart failure, indicating that galectin-3 could be used to evaluate the severity of the heart failure in the same nationality. The assessment of other ethnic groups was meaningless. (4) LAD of the same level Kazak heart dysfunction patients, LVEDD of the Han people with heart dysfunction, and the lower LVEF than the Han, indicated that the Kazak heart dysfunction was more serious than the Han nationality, and the correlation analysis showed that both Kazak and Han, galectin-3 and LAD LVEDD is positively correlated and negatively related to LVEF, while galectin-3 has a higher correlation with Kazak LAD, LVEDD, LVEF, indicating that galectin-3 is more accurate in evaluating the severity of cardiac remodeling in Kazak patients with cardiac insufficiency.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R541.6

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