發(fā)布時間：2018-06-11 16:10

  本文選題：舍曲林 + 心理干預　； 參考：《中國老年學雜志》2017年11期

【摘要】：目的探討舍曲林聯(lián)合心理干預對老年冠心病患者經皮冠狀動脈介入(PCI)后焦慮抑郁癥狀的改善情況及與血清白細胞介素(IL)-18、髓過氧化物酶(MPO)的相關性。方法 102例PCI手術伴有焦慮抑郁癥狀的冠心病患者102例隨機分為對照組54例,采用常規(guī)治療及給予安慰劑輔助治療,觀察組48例在對照組治療的基礎上給予鹽酸舍曲林片,并實施心理干預。結果治療后觀察組漢密頓焦慮量表(HAMA)評分、漢密頓抑郁量表(HAMD)評分均顯著低于對照組(均P0.05);觀察組血清IL-18、MPO水平明顯低于對照組(均P0.05);觀察組血清IL-18、MPO與HAMA評分呈正相關(均P0.001),血清IL-18、MPO與HAMD評分呈正相關(均P0.001)。結論舍曲林聯(lián)合心理干預治療可明顯改善介入治療冠心病患者術后焦慮抑郁癥狀,術后IL-18、MPO檢測可為患者的治療和預后研究提供靶點。
[Abstract]:Objective to investigate the effect of sertraline combined with psychological intervention on anxiety and depression after percutaneous coronary intervention (PCI) in elderly patients with coronary artery disease (CHD) and its correlation with interleukin-18 (IL-18) and myeloperoxidase (MPO). Methods 102 patients with coronary heart disease associated with anxiety and depression in PCI operation were randomly divided into control group (54 cases) and placebo adjuvant therapy. 48 cases in observation group were treated with sertraline hydrochloride on the basis of control group. Psychological intervention was carried out. Results the Hamilton anxiety scale (Hama) score in the observation group after treatment was higher than that in the control group. The scores of Hamd were significantly lower in the observation group than those in the control group (all P 0.05), the levels of IL-18 MPO in the observation group were significantly lower than those in the control group (all P 0.05), and there was a positive correlation between the serum IL-18 MPO and the Hama score in the observation group (P 0.001), and a positive correlation between the serum IL-18 MPO and the Hamd score in the observation group (all P 0.001). Conclusion Sertraline combined with psychological intervention can significantly improve anxiety and depression symptoms in patients with coronary heart disease after interventional therapy. The detection of IL-18 MPO can provide a target for the treatment and prognosis of patients with coronary heart disease.
【作者單位】： 商丘醫(yī)學高等專科學校護理系;鄭州市第六人民醫(yī)院心血管內科;
【基金】：商丘市2013年科技發(fā)展計劃科技攻關項目(No.131151)
【分類號】：R541.4;R749

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