本文選題：趨化因子CXC受體 + 趨化因子CXC配體��； 參考：《中國動脈硬化雜志》2017年12期

【摘要】：目的探討趨化因子CX3C受體1(CX3CR1)基因rs3732378單核苷酸多態(tài)性與急性冠狀動脈綜合征(ACS)的相關(guān)性。方法連續(xù)收集中國北方漢族人群951例,其中男性520例,女性431例,年齡35~75歲。根據(jù)冠狀動脈造影(CAG)結(jié)果分為2組:(1)病例組(n=512):ACS患者;(2)對照組(n=439):非冠心病患者。病例組根據(jù)CAG檢查血管病變支數(shù)分為3個亞組。采用測序法測定CX3CR1基因rs3732378單核苷酸多態(tài)位點的基因型。用多因素Logistic回歸分析CX3CR1基因rs3732378多態(tài)性與ACS發(fā)病風(fēng)險的關(guān)系。應(yīng)用酶聯(lián)免疫吸附法檢測血漿中趨化因子CX3C配體1(CX3CL1)表達水平。結(jié)果兩組CX3CR1基因rs3732378的基因型及等位基因的分布頻率無顯著性差異(P0.05)。rs3732378多態(tài)位點與ACS發(fā)病風(fēng)險的總體和分層分析結(jié)果表明,CX3CR1基因rs3732378多態(tài)位點的3種基因型TT、TC和CC均不能增加ACS的發(fā)病風(fēng)險(P0.05)。亞組分析顯示,rs3732378多態(tài)位點的基因型和等位基因與冠狀動脈血管病變支數(shù)無相關(guān)性(χ2=0.135,P=0.998;χ2=0.026,P=0.987)。病例組和對照組血漿中CX3CL1表達水平在rs3732378三種基因型無差異(P0.05)。結(jié)論 CX3CR1基因rs3732378多態(tài)位點不是ACS的易感基因,rs3732378多態(tài)性沒有增加中國北方漢族人群ACS的風(fēng)險。
[Abstract]:Objective to investigate the association between rs3732378 single nucleotide polymorphism of chemokine CX3C receptor (CX3C receptor 1) CX3CR1 gene and acute coronary syndrome (ACS). Methods 951 cases of Han nationality in northern China were collected, including 520 males and 431 females aged 35 to 75 years. According to the results of coronary angiography (CAG), the patients were divided into two groups: the control group (n = 512) and the control group (n = 439). The patients were divided into three subgroups according to the number of branches of angiopathy examined by CAG. The genotypes of rs3732378 single nucleotide polymorphisms of CX3 CR1 gene were determined by sequencing. Multivariate logistic regression analysis was used to analyze the relationship between CX3CR1 gene rs3732378 polymorphism and risk of ACS. Enzyme linked immunosorbent assay (Elisa) was used to detect the expression of CX3C ligand 1 (CX3CL1) in plasma. Results there was no significant difference in genotype and allelic frequency of CX3CR1 gene rs3732378 between the two groups. The overall and stratified analysis of the polymorphic locus rs3732378 and the risk of CX3CR1 gene rs3732378 showed that neither TTTC nor CC of CX3CR1 gene rs3732378 polymorphism locus was found. It can increase the risk of ACS (P 0.05). Subgroup analysis showed that there was no correlation between genotype and allele of rs3732378 polymorphic locus and the number of coronary artery lesion branches (蠂 ~ 2 + 0.135), 蠂 ~ (2 +) = 0.026 (P = 0.987). There was no difference in CX3CL1 expression among the three genotypes of rs3732378 between the case group and the control group (P 0.05). Conclusion the polymorphism of rs3732378 polymorphism of CX3CR1 gene does not increase the risk of ACS in Han population in northern China.
【作者單位】： 錦州醫(yī)科大學(xué)研究生學(xué)院;沈陽軍區(qū)總醫(yī)院心血管內(nèi)科;
【基金】：遼寧省科學(xué)技術(shù)計劃面上項目(2015020400)
【分類號】：R541.4
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本文編號：1999961