發(fā)布時間：2018-06-05 05:27

  本文選題：參芪扶正注射液 + 慢性心力衰竭�。� 參考：《蚌埠醫(yī)學(xué)院》2017年碩士論文

【摘要】：目的:觀察治療組與對照組治療前后的心功能療效、NT-proBNP、左心室射血分?jǐn)?shù)、左心室舒張末期內(nèi)徑、同型半胱氨酸、超敏C反應(yīng)蛋白與空腹血糖以及糖化血紅蛋白水平的改變,來評價參芪扶正注射液對慢性心力衰竭合并2型糖尿病患者的心功能療效以及對血糖水平的影響。方法:本研究收集了2015.5至2016.12期間在本院心內(nèi)科、心內(nèi)科重癥監(jiān)護(hù)室住院病人,且臨床明確診斷為慢性心力衰竭合并2型糖尿病患者,中醫(yī)證候分型為氣虛血瘀型,共150例,嚴(yán)格按照入選標(biāo)準(zhǔn)與排除標(biāo)準(zhǔn)篩選后,運(yùn)用隨機(jī)數(shù)字表法隨機(jī)分配到實(shí)驗(yàn)組和對照組,對照組采用持續(xù)低流量吸氧,基礎(chǔ)疾病治療,嚴(yán)格控制血糖,強(qiáng)心利尿劑,硝酸酯類血管緊張素Ⅱ受體拮抗劑(ARB),β受體阻斷劑(β-Block),醛固酮受體拮抗劑及擴(kuò)血管藥物等治療心力衰竭,均使用小劑量葉酸片口服,實(shí)驗(yàn)組在常規(guī)治療基礎(chǔ)上加予參芪扶正注射液(250ml)治療,1次/天,治療14天。結(jié)果:對照組與實(shí)驗(yàn)組治療前后心功能、血糖水平、HCY、hs-CRP均有不同程度改善。在降低N-端腦利鈉肽前體(NT-proBNP)水平上,實(shí)驗(yàn)組與對照組相比,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);治療后兩組患者的左心室射血分?jǐn)?shù)(LVEF)、左心室舒張末期內(nèi)徑(LVEDD)、心功能療效、超敏C反應(yīng)蛋白(hs-CRP)差異具有統(tǒng)計(jì)學(xué)意義(P0.05);治療后對照組與實(shí)驗(yàn)組同型半胱氨酸(HCY)水平未見明顯差異(P0.05);在降低血糖方面,實(shí)驗(yàn)組與對照組患者的空腹血糖(FBG)差異具有統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者治療前后糖化血紅蛋白(HbA1c)水平未見明顯差異(P0.05)。兩組患者治療中未出現(xiàn)明顯不良反應(yīng),安全性較好。結(jié)論:參芪扶正注射液能有效改善慢性心力衰竭合并2型糖尿病患者的心功能指標(biāo),能降低hs-CRP水平,并能有效降低患者的血糖水平,在常規(guī)診療過程中加用參芪扶正注射液可以提高臨床療效,且無明顯不良反應(yīng)。
[Abstract]:Objective: to observe the changes of NT-proBNP, left ventricular ejection fraction, left ventricular end-diastolic diameter, homocysteine, hypersensitive C-reactive protein, fasting blood glucose and glycosylated hemoglobin in the treatment group and control group before and after treatment. To evaluate the effect of Shenqi Fuzheng injection on heart function and blood glucose level in patients with chronic heart failure and type 2 diabetes. Methods: during the period from 2015.5 to 2016.12, we collected the hospitalized patients in the Department of Cardiology and intensive Care Unit of the Department of Cardiology, and the patients with type 2 diabetes mellitus were definitely diagnosed as chronic heart failure, and the TCM syndromes were classified as qi deficiency and blood stasis, a total of 150 cases. After screening according to the selection criteria and exclusion criteria, the experimental group and the control group were randomly assigned to the experimental group and the control group. The control group was treated with continuous low flow oxygen inhalation, basic disease treatment, strict control of blood glucose, and diuretics. Low dose folic acid tablets were used to treat heart failure with nitrates angiotensin 鈪，

本文編號：1980767