本文選題：原發(fā)性高血壓 + 血清尿酸��； 參考：《西安醫(yī)學(xué)院》2017年碩士論文

【摘要】：目的初步了解原發(fā)性高血壓患者中血尿酸的水平及高尿酸血癥的患病率,探討血尿酸水平與原發(fā)性高血壓患者血壓分級(jí)及危險(xiǎn)分層的相關(guān)性,希望能對(duì)臨床上原發(fā)性高血壓的早期防治、病情評(píng)估和治療預(yù)后有所幫助,以及為后續(xù)的血尿酸與原發(fā)性高血壓的深入研究提供參考。方法依據(jù)嚴(yán)格的入選標(biāo)準(zhǔn)隨機(jī)收取2016年1月-2016年12月于西安市西安醫(yī)學(xué)院第二附屬醫(yī)院就診的高血壓患者(研究組)138例,其中男性59例,女性79例,依據(jù)血壓水平分為1級(jí)高血壓組69例、2級(jí)高血壓組37例、3級(jí)高血壓組32例。再依據(jù)危險(xiǎn)分層分為低危組39例、中危組33例、高危組32例、很高危組34例。另選取同期參加體檢的健康患者(對(duì)照組)61例,其中男24例,女37例。分別測(cè)定各組血清尿酸水平及高尿酸血癥患病率,分析血清尿酸水平是否與原發(fā)性高血壓具有一定的相關(guān)性。結(jié)果1、高血壓組血尿酸的水平為317.41±106.91 umol/L,明顯高于對(duì)照組223.64±62.69umol/L的尿酸水平,p0.05,其高血壓組高尿酸血癥的患病率為18.1%,亦明顯高于對(duì)照組3.3%的高尿酸血癥的患病率,p0.05。高血壓組男性血尿酸水平為363.12±113.28 umol/L,女性284.01±88.84 umol/L,分別高于對(duì)照組249.04±73.96 umol/L及207.16±48.44 umol/L的尿酸水平,p0.05。無(wú)論高血壓組還是對(duì)照組,血尿酸水平均為男性高于女性,p0.05。2、3級(jí)高血壓組血尿酸水平424.22±94.24 umol/L,高尿酸血癥的患病率34.4%,2級(jí)高血壓組血尿酸水平332.84±76.53 umol/L,高尿酸血癥的患病率為21.6%,1級(jí)高血壓組血尿酸水平259.59±83.59 umol/L,高尿酸血癥的患病率為8.7%,3組之間血尿酸水平及高尿酸血癥的患病率均有顯著性差異,p0.05。3、高血壓很高危組血尿酸的水平為423.85±82.48 umol/L,高尿酸血癥的患病率為32.4%,高危組血尿酸的水平為360.91±75.71 umol/L,高尿酸血癥的患病率21.9%,中危組血尿酸的水平為288.58±61.56 umol/L,高尿酸血癥的患病率為12.1%,低危組血尿酸的水平為213.31±62.10 umol/L,高尿酸血癥的患病率為7.7%,4組之間血尿酸水平及高尿酸血癥的患病率均有顯著性差異,p0.05。結(jié)論1、原發(fā)性高血壓患者存在血尿酸水平及高尿酸血癥患病率明顯升高的表現(xiàn),且男性血尿酸水平顯著高于女性。2、原發(fā)性高血壓患者血壓分級(jí)越高,其血尿酸水平及高尿酸血癥患病率越高,反之,血壓分級(jí)越低,血尿酸水平及高尿酸血癥患病率越低。3、原發(fā)性高血壓患者危險(xiǎn)分層越高,其血尿酸水平及高尿酸血癥患病率越高,反之,危險(xiǎn)分層越低,血尿酸水平及高尿酸血癥患病率越低。4、血尿酸水平升高與原發(fā)性高血壓密切相關(guān),是高血壓的危險(xiǎn)因素之一,其可能參與高血壓的致病、進(jìn)程及預(yù)后,在臨床檢測(cè)中具有重要的應(yīng)用價(jià)值,可為疾病的早期防治、病情評(píng)估和治療預(yù)后提供重要參考。
[Abstract]:Objective to investigate the level of serum uric acid and the prevalence of hyperuricemia in patients with essential hypertension, and to explore the correlation between serum uric acid levels and blood pressure grading and risk stratification in patients with essential hypertension. It is hoped that it will be helpful to the early prevention and treatment of primary hypertension in clinic, to the evaluation of the condition and the prognosis of treatment, and to the further study of serum uric acid and essential hypertension. Methods according to strict selection criteria, 138 hypertensive patients (59 males and 79 females) who were admitted to the second affiliated Hospital of Xi'an Medical College in Xi'an City from January 2016 to December 2016 were randomly selected. According to blood pressure level, there were 69 cases of grade 1 hypertension group and 37 cases of grade 3 hypertension group. According to the risk stratification, 39 cases were divided into low risk group, 33 middle risk group, 32 high risk group and 34 very high risk group. In addition, 61 healthy patients (control group, 24 males and 37 females) were selected. The serum uric acid level and the prevalence rate of hyperuricemia were measured, and the correlation between serum uric acid level and essential hypertension was analyzed. Results 1 the level of serum uric acid in hypertension group was 317.41 鹵106.91 umol/ L, which was significantly higher than that in control group (223.64 鹵62.69umol/L) (p 0.05). The prevalence of hyperuricemia in hypertension group was 18.1% and significantly higher than that in control group (3.3%). The serum uric acid levels in the hypertension group were 363.12 鹵113.28 umol/ L and 284.01 鹵88.84 umol / L, respectively, which were higher than those in the control group at 249.04 鹵73.96 umol/L and 207.16 鹵48.44 umol/L, respectively. Whether the hypertension group or the control group, The levels of serum uric acid in males were higher than those in females in grade 3 hypertension group (424.22 鹵94.24 umol / L), the prevalence rate of hyperuricemia was 332.84 鹵76.53 umol/ L in grade 2 hypertension group, and the prevalence rate of hyperuricemia group was 259.59 鹵83.59 in grade 1 hypertension group. Umolr / L, the prevalence of hyperuricemia was 8.7U / L and the prevalence of hyperuricemia was significantly different among the three groups (p 0.05.3). The level of serum uric acid in the high risk group was 423.85 鹵82.48 umol / L, the prevalence rate of hyperuricemia was 32.4%, and the prevalence rate of hyperuricemia was 32.4b in the high risk group. The level of acid was 360.91 鹵75.71 umol/ L, the prevalence rate of hyperuricemia was 21.9, the level of serum uric acid in moderate risk group was 288.58 鹵61.56 umolr / L, the prevalence rate of hyperuricemia was 12.1umol / L, the level of serum uric acid in low-risk group was 213.31 鹵62.10 umol/ L, and the prevalence rate of hyperuricemia was 7.7U / L among the four groups. There was a significant difference between the prevalence rate of ping and hyperuricemia (P 0.05). Conclusion 1. The serum uric acid level and the prevalence rate of hyperuricemia in patients with essential hypertension were significantly higher than those in women. The higher the blood pressure grade was in patients with essential hypertension, the higher the level of serum uric acid was. The higher the level of serum uric acid and the prevalence of hyperuricemia, the lower the blood pressure grade, the lower the serum uric acid level and the prevalence rate of hyperuricemia, the higher the risk stratification of essential hypertension. The higher the level of serum uric acid and the prevalence of hyperuricemia, the lower the risk stratification, the lower the prevalence rate of serum uric acid and hyperuricemia, and the higher the level of serum uric acid is associated with essential hypertension, which is one of the risk factors of hypertension. It may be involved in the pathogenesis, progression and prognosis of hypertension. It has important application value in clinical detection, and can provide important reference for early prevention, treatment and prognosis of the disease.
【學(xué)位授予單位】：西安醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R544.11

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 羅成建;歐玉珍;劉洋;;2型糖尿病患者尿酸水平與腎功能關(guān)系[J];中國(guó)醫(yī)學(xué)創(chuàng)新;2017年04期

2 李娜;高月琴;;高尿酸血癥與冠心病關(guān)系的研究進(jìn)展[J];中國(guó)當(dāng)代醫(yī)藥;2016年32期

3 白堯勇;龍超年;;我國(guó)高血壓病流行特征及防治策略[J];疾病監(jiān)測(cè)與控制;2016年09期

4 陳偉偉;高潤(rùn)霖;劉力生;朱曼璐;王文;王擁軍;吳兆蘇;李惠君;顧東風(fēng);楊躍進(jìn);鄭哲;蔣立新;胡盛壽;;《中國(guó)心血管病報(bào)告2015》概要[J];中國(guó)循環(huán)雜志;2016年06期

5 司美君;葉增純;趙文波;張笑浩;李吟;劉迅;彭暉;婁探奇;;2型糖尿病合并慢性腎臟病患者的腎臟病理與臨床表現(xiàn)特點(diǎn)[J];中華腎臟病雜志;2016年06期

6 周亞?wèn)|;劉曉紅;張永強(qiáng);郭明賢;;陜西省農(nóng)村老年人高血壓患者知曉率治療率和控制率的現(xiàn)況調(diào)查研究[J];中國(guó)預(yù)防醫(yī)學(xué)雜志;2016年03期

7 鄭敏;麻駿武;;高尿酸血癥和痛風(fēng)的遺傳學(xué)研究進(jìn)展[J];遺傳;2016年04期

8 王翠平;肖水源;劉永泉;江初;王洪波;;北京海淀區(qū)成人高血壓防控現(xiàn)狀及影響因素分析[J];實(shí)用預(yù)防醫(yī)學(xué);2015年10期

9 楊U，

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