本文選題：原發(fā)性高血壓 + 乙醛脫氫酶2��； 參考：《新疆醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的：探討ALDH2基因rs671多態(tài)性在新疆地區(qū)漢族人群原發(fā)性高血壓(Essential hypertension)發(fā)病中的作用。方法：應(yīng)用Taqman技術(shù)檢測了474例漢族EH患者和358例正常血壓者ALDH2基因rs671多態(tài)性。結(jié)果：(1)在男性人群,飲酒組rs671的GA+AA基因型頻率和A等位基因頻率均明顯低于男性不飲酒組(P0.001)；(2)在男性人群EH組rs671的GA+AA基因型頻率和A等位基因頻率均明顯低于對照組(P=0.006和P=0.007),而在女性人群EH組和對照組rs671的3種基因型頻率和等位基因頻率的分布差異無統(tǒng)計(jì)學(xué)意義(P=0.202和P=0.108)；(3)非條件logistic回歸分析平衡年齡、體重指數(shù)、糖尿病史、飲酒史等影響因素后,在男性人群rs671的GA+AA基因型者患EH的風(fēng)險(xiǎn)明顯低于GG基因型者(OR=0.656, 95%CI:0.448-0.962, P=0.031)。(4)在男性飲酒者中,GA+AA基因型者收縮壓水平明顯低GG型者(P=0.021),而在男性不飲酒者和女性人群中,GA+AA基因型者和GG基因型者血壓水平的差異無統(tǒng)計(jì)學(xué)意義。結(jié)論：ALDH2基因rs671多態(tài)性可能和新疆漢族男性人群EH的發(fā)生相關(guān),rs671的GA+AA基因型可能是漢族男性人群EH的一個保護(hù)因素。
[Abstract]:Objective: to investigate the role of ALDH2 gene rs671 polymorphism in the pathogenesis of essential hypertension in Xinjiang Han population. Methods: ALDH2 gene rs671 polymorphism was detected by Taqman technique in 474 EH patients of Han nationality and 358 normal blood pressure subjects. It turns out that in the male population, GA-AA genotype frequency and A allele frequency of rs671 in drinking group were significantly lower than those in non-drinking male group (P0.001). The frequency of GA AA genotype and A allele in rs671 in male EH group were significantly lower than those in control group P0.006 and P0. 007, but in female, they were significantly lower in EH group than in control group (P 0. 006 and P 0. 007). There was no significant difference in the distribution of genotype frequency and allele frequency of rs671 between EH group and control group. There was no significant difference in the distribution of genotype frequency and allele frequency between EH group and control group (P < 0. 202 and P < 0. 108). Body mass index (BMI), history of diabetes, history of alcohol consumption and other factors, The risk of EH in men with GA AA genotype of rs671 was significantly lower than that of those with GG genotype OR0.656, 95 CI: 0.448-0.962, P0. 031 1, P0. 4) in male drinkers, the systolic blood pressure level of GG AA genotype was significantly lower than that of GG genotype AA genotype, while in male drinkers and female population, GA-AA genotype had significantly lower systolic blood pressure level, while in male non-drinkers and female population, GA-AA genotype had significantly lower systolic blood pressure. There was no significant difference in blood pressure between AA genotype and GG genotype. Conclusion the rs671 polymorphism of the 1: ALDH2 gene may be associated with the occurrence of EH in Xinjiang Han population, and the GA AA genotype of rs671 may be a protective factor for EH in Han Chinese.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R544.11

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相關(guān)期刊論文 前1條

1 弭守玲;范凡;李紀(jì)明;付明強(qiáng);孫愛軍;葛均波;;乙醛脫氫酶2基因多態(tài)性在上海市與山東省漢族人群中的分布差異[J];中國臨床醫(yī)學(xué);2011年06期

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本文編號：1969476