本文選題：非瓣膜性房顫 + 華法林��； 參考：《中國藥房》2017年27期

【摘要】：目的:為改善非瓣膜性房顫患者用藥依從性,更好地保證治療安全性和有效性提供參考。方法:選取部分在我院住院接受華法林抗凝治療的非瓣膜性房顫患者進行問卷調(diào)查,分別采用8條目Morisky用藥依從性量表(MMAS-8)和華法林用藥知識量表(WRKS)評估患者華法林用藥依從性及抗凝治療相關(guān)知識知曉情況,并應(yīng)用χ2檢驗、t檢驗及Logistic多元回歸分析方法探討影響患者華法林用藥依從性的相關(guān)因素。結(jié)果:共發(fā)放問卷129份,回收有效問卷112份,有效回收率為86.82%。受訪患者MMAS-8平均得分為(6.54±1.61)分,用藥依從性好者占42.86%。受訪患者WRKS平均得分為(7.95±1.65)分,用藥依從性好者平均得分為(9.31±0.83)分,用藥依從性差者平均得分為(6.92±1.34)分。單因素分析發(fā)現(xiàn),用藥依從性好者與用藥依從性差者在性別、年齡、職業(yè)、文化程度、合并癥種數(shù)、WRKS得分等方面比較,差異均有統(tǒng)計學(xué)意義(P0.05)。Logistic多元回歸分析結(jié)果顯示,WRKS得分、性別、文化程度、合并癥種數(shù)與受訪患者用藥依從性均顯著相關(guān)(P0.05)。結(jié)論:非瓣膜性房顫患者華法林用藥依從性較差,與多種影響因素相關(guān),其中華法林抗凝治療相關(guān)知識知曉情況是一個重要因素。
[Abstract]:Objective: to improve the compliance of patients with non-valvular atrial fibrillation and to ensure the safety and efficacy of the treatment. Methods: some non-valvular atrial fibrillation patients who received warfarin anticoagulant therapy in our hospital were investigated by questionnaire. Morisky compliance scale (MMAS-8) and warfarin drug knowledge scale (WRKS) were used to evaluate warfarin compliance and knowledge of anticoagulant therapy. 蠂 2 test and Logistic multiple regression analysis were used to study the factors influencing the compliance of warfarin. Results: 129 questionnaires were sent out, 112 valid questionnaires were collected, and the effective recovery rate was 86.82. The average score of MMAS-8 was 6.54 鹵1.61, and 42.86 had good compliance. The average score of WRKS was 7.95 鹵1.65, the average score of patients with good compliance was 9.31 鹵0.83), the average score of patients with poor compliance was 6.92 鹵1.34. Univariate analysis showed that there were significant differences in sex, age, occupation, education level and WRKS score between the patients with good compliance and those with poor compliance. The results of multiple logistic regression analysis showed that the scores of WRKS were significant. Sex, education level and the number of patients with complications were significantly correlated with drug compliance (P 0.05). Conclusion: warfarin compliance in patients with non-valvular atrial fibrillation is poor, which is related to many factors, among which warfarin anticoagulant therapy knowledge is an important factor.
【作者單位】： 泰山醫(yī)學(xué)院附屬醫(yī)院藥劑科;泰山醫(yī)學(xué)院附屬醫(yī)院心內(nèi)科;
【基金】：泰山醫(yī)學(xué)院附屬醫(yī)院青年科學(xué)基金計劃項目(No.2014QN05)
【分類號】：R541.75

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