發(fā)布時(shí)間：2018-05-25 20:56

  本文選題：收縮壓 + 頸動(dòng)脈內(nèi)膜中層厚度��； 參考：《華北理工大學(xué)》2017年碩士論文

【摘要】：目的探究在老年人群中診室、隨診間、24小時(shí)動(dòng)態(tài)收縮壓(systolic blood pressure,SBP)與頸動(dòng)脈內(nèi)膜中層厚度(carotid intima-media thickness,CIMT)的相關(guān)性。方法開(kāi)灤集團(tuán)在2006-2007年度開(kāi)展了包括在職和離退休職工的第一次健康體檢,此后每?jī)赡赀M(jìn)行一次體檢,填寫(xiě)調(diào)查問(wèn)卷并收集相關(guān)體檢數(shù)據(jù),并在2010-2011年度體檢時(shí)隨機(jī)抽取在開(kāi)灤總醫(yī)院、開(kāi)灤林西醫(yī)院、開(kāi)灤趙各莊醫(yī)院體檢中的部分退休職工2814例,另外選擇時(shí)間行診室血壓測(cè)量、24小時(shí)動(dòng)態(tài)血壓監(jiān)測(cè)、頸動(dòng)脈彩超等檢查,符合納入和排除標(biāo)準(zhǔn)的為2464例,最終資料完整的1423例納入統(tǒng)計(jì)分析。按照診室、隨診間、24小時(shí)、日間、夜間SBP的三分位數(shù)分別將研究對(duì)象分為三組,采用方差分析比較組間CIMT的平均值;采用Pearson相關(guān)和偏相關(guān)分析診室、隨診間、24h、日間、夜間SBP與CIMT的關(guān)聯(lián);采用共線(xiàn)性診斷檢驗(yàn)變量間共線(xiàn)性問(wèn)題,并用逐步線(xiàn)性回歸分別和同時(shí)分析上述SBP對(duì)CIMT的影響。結(jié)果1 1423例研究人群(男性、女性分別為940例、483例)的平均年齡為67.11±5.85歲,CIMT的平均值為0.92±0.18mm。2按照不同SBP三分位數(shù)分別將研究對(duì)象分為三組,CIMT隨不同SBP水平升高呈增加趨勢(shì)(P0.001)。3Pearson相關(guān)及偏相關(guān)分析顯示診室、隨診間、24小時(shí)、日間、夜間SBP與CIMT的相關(guān)系數(shù)在0.152~0.219之間(P0.001)。4校正影響因素后的逐步回歸分析顯示:上述SBP分別與CIMT呈線(xiàn)性相關(guān),隨著各SBP增加10mm Hg,對(duì)應(yīng)的CIMT分別增加0.013mm、0.022mm、0.023mm、0.022mm、0.019mm(P均0.001)。去除共線(xiàn)性最大的24h SBP后,同時(shí)分析不同SBP對(duì)CIMT影響大小,結(jié)果顯示隨診間和日間SBP與CIMT呈線(xiàn)性相關(guān),β分別為0.151、0.104。結(jié)論1診室、隨診間、24h、日間、夜間SBP與CIMT均存在關(guān)聯(lián)。2隨診間和日間SBP與CIMT的關(guān)聯(lián)優(yōu)于診室SBP,且隨診間SBP優(yōu)于日間SBP。
[Abstract]:Objective to investigate the relationship between systolic blood pressure (SBP) and carotid intima-media thickness (IMT) in elderly patients. Methods Kailuan Group carried out the first physical examination in 2006-2007, which included in-service and retired workers, and every two years thereafter, completed the questionnaire and collected the relevant physical data. At the time of physical examination in 2010-2011, 2814 retired workers were randomly selected from Kailuan General Hospital, Kailuan Linxi Hospital and Kailuan Zhaogezhuang Hospital. In addition, 24 hours ambulatory blood pressure monitoring was performed in the clinic. According to the criteria of inclusion and exclusion, 2464 cases were examined by carotid color ultrasound, and 1423 cases with complete data were included in the statistical analysis. According to the three-digit number of SBP in the clinic, 24 hours follow-up room, daytime and night, the subjects were divided into three groups. The mean value of CIMT was compared by ANOVA, the Pearson correlation and partial correlation analysis were used, the follow-up interval was 24 hours, the day interval was 24 hours, and the mean value of CIMT in each group was compared by ANOVA. The correlation between SBP and CIMT at night and collinear diagnosis were used to test the collinearity problem between variables. The influence of SBP on CIMT was analyzed separately and simultaneously by stepwise linear regression. Results 1 1423 subjects (male, male) were included in the study. The average age of 67.11 鹵5.85 years old was 0.92 鹵0.18mm.2. The subjects were divided into three groups according to the three digits of different SBP. The three groups were divided into three groups with the increase of SBP level (P 0.001). 3 Pearson correlation analysis and partial correlation analysis showed that the patients were in the clinic, and the results were as follows: (1) the average age of the women was 67.11 鹵5.85 years old, and the mean age was 0.92 鹵0.92 鹵0.92 鹵0.92 鹵0.92 鹵0.92% respectively. The stepwise regression analysis showed that the correlation coefficient between SBP and CIMT was 0.152 鹵0.219 in daytime and 0.152 鹵0.219 in night, respectively. The stepwise regression analysis showed that the above SBP was linearly correlated with CIMT, and the CIMT increased by 0.013 mm / 0.022 mm / 0. 022 mm / 0. 019 mm / h respectively (P = 0. 001) with the increase of SBP. After removing the maximum co-linear SBP for 24 hours, the influence of different SBP on CIMT was analyzed. The results showed that SBP was linearly correlated with CIMT (尾 = 0.151) and CIMT (尾 = 0.104). Conclusion (1) in the diagnosis room, there was a correlation between SBP and CIMT at night and between SBP and CIMT in daytime, and the SBP in follow-up room was better than that in SBP in day. 2. The relationship between SBP and CIMT in night and in night was better than that in SBP in clinic. The SBP in follow-up room was better than that in SBP in day.
【學(xué)位授予單位】：華北理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R544.1

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本文編號(hào)：1934644