本文選題：心力衰竭 + 胱抑素C�。� 參考：《重慶醫(yī)學(xué)》2017年27期

【摘要】：目的研究血漿腦鈉肽(BNP)與血清胱抑素C(Cys C)對致心律失常型右室心肌病(ARVC)引起的心力衰竭的預(yù)測價值。方法選擇32例ARVC病例,檢測其血漿BNP及血清Cys C水平,并隨訪18個月觀察心力衰竭發(fā)生情況。結(jié)果 ARVC患者入院時的血漿BNP、血清Cys C水平均隨心功能的降低而呈上升趨勢,不同心功能組的差異均有統(tǒng)計學(xué)意義(P0.05)。多因素Logistic回歸分析顯示,血漿BNP(OR=4.118)、血清Cys C(OR=6.358)是ARVC患者心力衰竭的獨立預(yù)測因子。當(dāng)BNP與Cys C分別取732.45ng/L與2.16mg/L時,對心力衰竭預(yù)測的靈敏度與特異度均為最高。以隨訪出現(xiàn)心力衰竭為終點結(jié)局進行生存分析,BNP低危組(≤732.45ng/L)的生存率高于高危組(P0.01);Cys C低危組(≤2.16mg/L)的生存率也高于高危組(P0.01)。結(jié)論血漿BNP與血清Cys C水平對于ARVC導(dǎo)致的心力衰竭有較高的預(yù)測價值。
[Abstract]:Objective to study the predictive value of plasma brain natriuretic peptide (BNP) and serum cystatin (C(Cys C) in heart failure induced by arrhythmogenic right ventricular cardiomyopathy. Methods Plasma BNP and serum Cys C levels were measured in 32 patients with ARVC. The incidence of heart failure was observed after 18 months follow-up. Results the levels of plasma BNP and serum Cys C in patients with ARVC increased with the decrease of cardiac function, and there were significant differences among different heart function groups (P 0.05). Multivariate Logistic regression analysis showed that plasma BNPO 4.118 and serum Cys OR6.358 were independent predictors of heart failure in patients with ARVC. When 732.45ng/L and 2.16mg/L were selected for BNP and Cys C, the sensitivity and specificity for predicting heart failure were the highest. Survival analysis at the end of follow-up of patients with heart failure; the survival rate of BNP low risk group (鈮，

本文編號：1896576