發(fā)布時(shí)間：2018-05-12 13:42

  本文選題：高血脂 + 胸主動(dòng)脈��； 參考：《臨床放射學(xué)雜志》2017年11期

【摘要】：目的應(yīng)用磁共振管壁成像技術(shù)探討老年人胸主動(dòng)脈粥樣硬化斑塊的特征及其與高血脂的相關(guān)性。方法入組人群為60歲以上、且無任何嚴(yán)重心腦血管癥狀的老年人。所有受試者均進(jìn)行胸主動(dòng)脈多對(duì)比度磁共振管壁成像。圖像判讀人員將定量測(cè)量高血脂者和血脂正常者胸主動(dòng)脈粥樣硬化斑塊的負(fù)荷特征,定性分析其成分特征,并探討這些特征與高血脂的相關(guān)性。將胸主動(dòng)脈分為3段,即升主動(dòng)脈段(AAO)、主動(dòng)脈弓段(AOA)以及降主動(dòng)脈段(DAO)。結(jié)果 66例受試者,高血脂組43例,平均年齡(72.7±6.8)歲,其中男19例(44.2%)。高血脂組胸主動(dòng)脈粥樣硬化斑塊的發(fā)生率顯著高于血脂正常組(95.3%vs 60.9%,P=0.001)。同時(shí),富含脂質(zhì)壞死核(LRNC)的發(fā)生率亦顯著高于血脂正常組(88.4%vs 52.2%,P=0.001),而斑塊內(nèi)出血/血栓(IPH/MT)的差異無統(tǒng)計(jì)學(xué)意義(20.9%vs 21.7%,P=0.939)。高血脂組胸主動(dòng)脈3個(gè)節(jié)段的管腔面積(LA)均小于血脂正常組,而管壁面積(WA)及最大管壁厚度(maxWT)均大于血脂正常組,且差異均具有統(tǒng)計(jì)學(xué)意義(P0.05)。另外,胸主動(dòng)脈AS斑塊(OR=-0.311,P=0.011)及LRNC(OR=-0.591,P0.001)均與高密度脂蛋白呈顯著負(fù)相關(guān)。IPH/MT與甘油三酯呈顯著正相關(guān)(OR=0.25,P=0.043)。結(jié)論高血脂的老年人胸主動(dòng)脈粥樣硬化斑塊的發(fā)生率顯著高于血脂正常者,LRNC為其主要成分,并且與高密度脂蛋白的降低顯著相關(guān)。
[Abstract]:Objective to investigate the characteristics of thoracic aortic atherosclerotic plaque and its correlation with hyperlipidemia in the elderly by magnetic resonance wall imaging. Methods the elderly over 60 years old and without any serious cardiovascular and cerebrovascular symptoms were enrolled in the study. All subjects underwent multi-contrast magnetic resonance wall imaging of thoracic aorta. Image interpreters will quantitatively measure the load characteristics of thoracic aorta atherosclerotic plaques in hyperlipidemia and normolipidemia and qualitatively analyze their component characteristics and explore the correlation between these characteristics and hyperlipidemia. The thoracic aorta was divided into three segments: AAOA, AOAA, and DAOA in descending aorta. Results among 66 subjects, 43 cases were in hyperlipidemia group, with an average age of 72.7 鹵6.8 years, of which 19 cases were male. The incidence of atherosclerotic plaque in thoracic aorta in hyperlipidemia group was significantly higher than that in normal blood lipid group (95.3 vs 60.9). At the same time, the incidence of LRNCrich in lipid necrosis nucleus was significantly higher than that in normal blood lipid group (88. 4 vs 52. 22), while there was no significant difference in plaque hemorrhage / thrombus IPH / MTT between 20. 9 vs 21. 7 and 0. 939. The lumen area of three segments of thoracic aorta in hyperlipidemia group was smaller than that in normal blood lipid group, and the wall area (WAA) and maximum wall thickness (maxWTT) were larger than those in normal blood lipid group, and the difference was statistically significant (P 0.05). In addition, there was a significant negative correlation between OR-0.311P0. 011) and LRNCnC OR-0.591 (P0.001). There was a significant positive correlation between IPH / MT and triglyceride. Conclusion the incidence of atherosclerotic plaque in thoracic aorta of the elderly with hyperlipidemia is significantly higher than that with normal blood lipids, LRNC is the main component, and is significantly related to the decrease of high density lipoprotein.
【作者單位】： 揚(yáng)州大學(xué)附屬醫(yī)院放射科;東南大學(xué)附屬中大醫(yī)院放射科;清華大學(xué)生物醫(yī)學(xué)工程系生物醫(yī)學(xué)影像研究中心;美國華盛頓大學(xué)放射科;
【分類號(hào)】：R445.2;R543.5;R589.2

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