本文選題：急性冠狀動(dòng)脈綜合征 + 可溶性Fas��； 參考：《重慶醫(yī)學(xué)》2017年35期

【摘要】：目的探討可溶性Fas(sFas)和可溶性凝集素樣氧化低密度脂蛋白受體-1(sLOX-1)水平與急性冠狀動(dòng)脈綜合征(ACS)發(fā)生、發(fā)展的相關(guān)性。方法選取經(jīng)冠狀動(dòng)脈造影(CAG)確診的ACS患者52例(ACS組),其中不穩(wěn)定型心絞痛(UA)23例(UA組)、急性心肌梗死(AMI)29例(AMI組);另選取同期CAG證實(shí)冠狀動(dòng)脈無狹窄者58例作為對(duì)照組(NC組)。采用酶聯(lián)免疫吸附試驗(yàn)測(cè)定血清sFas、sLOX-1水平。結(jié)果與NC組比較,ACS組患者血清sFas、sLOX-1水平升高(P0.01);UA組和AMI組患者血清sFas、sLOX-1水平均高于NC組,且AMI組患者血清sFas、sLOX-1水平高于UA組(均P0.01)。ACS患者血清sFas與sLOX-1水平呈明顯正相關(guān)(r=0.825,P=0.001),但二者與肌酸激酶同工酶MB(CK-MB)、肌鈣蛋白I(cTnI)無明顯相關(guān)性(P0.05)。結(jié)論血清高水平sFas和sLOX-1可能是ACS的危險(xiǎn)因素。
[Abstract]:Objective to investigate the relationship between the levels of soluble FasS Fas1 and soluble lectin-like oxidized low density lipoprotein receptor-1 and ACSs in patients with acute coronary syndrome (ACS). Methods Fifty-two patients with ACS diagnosed by coronary angiography (CAG), including 23 patients with unstable angina pectoris and 29 patients with acute myocardial infarction (AMI), were selected as control group, and 58 patients with CAG with no coronary artery stenosis were selected as control group. The serum levels of sFas-sLOX-1 were measured by enzyme linked immunosorbent assay (Elisa). Results compared with NC group, the serum levels of sFas-sLOX-1 in ACS group were higher than those in NC group. The serum levels of sFas-sLOX-1 in patients with AMI were significantly higher than those in patients with UA (the levels of sFas and sLOX-1 were positively correlated with those of patients with P0.01).ACS, but there was no significant correlation between them and creatine kinase isoenzyme MBCK-MBN, troponin I ~ (2 +) cTnI) (P0.055.The serum levels of sFas-sLOX-1 in patients with P0.01).ACS were significantly higher than those in patients with UA (P < 0.05). Conclusion the high serum levels of sFas and sLOX-1 may be risk factors for ACS.
【作者單位】： 濟(jì)南大學(xué)山東省醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與生命科學(xué)學(xué)院;山東省醫(yī)學(xué)科學(xué)院附屬醫(yī)院心內(nèi)科;山東省醫(yī)學(xué)科學(xué)院附屬醫(yī)院醫(yī)務(wù)部;濱州醫(yī)學(xué)院附屬醫(yī)院心內(nèi)科;
【分類號(hào)】：R541.4

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