紋理分析用于心肌淀粉樣變性和肥厚型心肌病鑒別診斷的可行性研究
發(fā)布時(shí)間:2018-05-03 05:31
本文選題:紋理分析 + 磁共振成像 ; 參考:《放射學(xué)實(shí)踐》2017年12期
【摘要】:目的:評(píng)價(jià)磁共振成像結(jié)合紋理分析技術(shù)對(duì)心肌淀粉樣變性與肥厚型心肌病的鑒別診斷價(jià)值。方法:經(jīng)心內(nèi)膜活檢證實(shí)的心肌淀粉樣變性輕鏈型(CA)患者18例及經(jīng)臨床確診的肥厚型心肌病患者18例,均采用3.0T MR標(biāo)準(zhǔn)化掃描獲得電影序列圖像,使用TexRad軟件對(duì)所有患者左心室中段兩腔短軸位圖像進(jìn)行取樣分析,選擇不同的空間縮放因子(SSF,取值為0和2~6),獲得在不同紋理過濾尺度下代表紋理特征的5個(gè)參數(shù)值(包括均值、標(biāo)準(zhǔn)差、峰度、偏度、熵值),采用Mann-Whitney U檢驗(yàn)進(jìn)行組間比較,并使用ROC曲線評(píng)估各參數(shù)的診斷效能。結(jié)果:心肌淀粉樣變性和肥厚型心肌病的熵值、峰度和偏度間的差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。診斷心肌淀粉樣變性ROC曲線分析結(jié)果顯示,SSF=3時(shí)取熵值≥2.68,診斷淀粉樣變性的曲線下面積最大(0.87),診斷敏度87.2%,特異度為90.9%、符合率為88.0%。結(jié)論:紋理分析可用于心肌淀粉樣變性和肥厚型心肌病的鑒別診斷,相比傳統(tǒng)鑒別方法具有無需使用對(duì)比劑且縮短檢查時(shí)間的優(yōu)勢。
[Abstract]:Objective: to evaluate the value of magnetic resonance imaging (MRI) combined with texture analysis in the differential diagnosis of myocardial amyloidosis and hypertrophic cardiomyopathy. Methods: eighteen patients with myocardial amyloidosis and 18 patients with hypertrophic cardiomyopathy confirmed by endocardial biopsy were studied. TexRad software was used to sample and analyze two lumen short axial images of left ventricular middle segment in all patients. Different spatial scaling factors were selected, the values were 0 and 2 脳 6, and five parameters (including mean value) representing texture feature were obtained at different texture filtering scales. Standard deviation, kurtosis, deviation and entropy were compared by Mann-Whitney U test and ROC curve was used to evaluate the diagnostic efficiency of each parameter. Results: there were significant differences in entropy, kurtosis and bias between myocardial amyloidosis and hypertrophic cardiomyopathy (P 0.05). The results of ROC curve analysis of myocardial amyloidosis showed that the entropy value 鈮,
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