本文選題：幽門螺桿菌 + 動脈粥樣硬化性心臟病��； 參考：《大理大學(xué)》2017年碩士論文

【摘要】：目的:探討大理地區(qū)人群中幽門螺桿菌(Helicobacter pylori, Hp)感染情況與動脈粥樣硬化性心臟病(Coronary atherosclerotic heart disease, CHD)的相關(guān)性,進一步探討CHD患者HP感染與血脂、同型半胱氨酸(Homocysteine, Hcy)、超敏 C 反應(yīng)蛋白(High-sensitivity c-reactive protein,hs-CRP)、胱抑素 C (Cystatin C,CysC)的關(guān)系,及探討不同幽門螺桿菌菌株與冠心病的相關(guān)性,為研究冠心病的診斷與治療提供理論依據(jù)。方法:根據(jù)冠脈造影的結(jié)果,將2016年1月～2016年12月在大理大學(xué)附屬醫(yī)院住院治療122例冠心病患者分為冠心病HP感染組82例和冠心病非HP感染組40例。將同期健康體檢的837體檢者分為健康體檢HP陽性感染278例和健康體檢HP陰性559例。所有病例行血脂、HP、Hcy、hs-CRP、CysC等指標的檢測。應(yīng)用SPSS 17.0軟件進行數(shù)據(jù)處理,計量資料均以x±s表示,組間比較采用t檢驗,計數(shù)資料比較采用卡方檢驗,以P0.05表示差異有統(tǒng)計學(xué)意義。應(yīng)用多元Logistic回歸分析危險因素對冠心病的影響。結(jié)果:大理地區(qū)體檢人群中幽門螺桿菌總感染為33.21%,男性感染率為35.06%,女性感染率為30.93%。122例CHD患者中HP感染陽性者82例,CHD患者HP感染率為67.21%。HP感染組血清Hcy濃度明顯高于非感染組。冠心病患者中HP感染組Hcy、CysC、hs-CRP、TC、TG、LDL濃度水平明顯高于HP感染陰性組患者,差異有統(tǒng)計學(xué)意義(P0.05),而HDL低于HP感染陰性組患者。Ⅰ型Hp菌株感染患者血漿HCY和hs-CRP水平顯著高于Ⅱ型Hp菌株患者,組間差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:Hp感染與冠心病患者的Hcy、CysC、hs-CRP、TC、TG、LDL和HDL間存在相關(guān)性,Hp感染可能引起血脂異常、炎性反應(yīng)、Hcy升高等心血管危險因素,以促使斑塊的形成和斑塊的不穩(wěn)定,在動脈粥樣硬化發(fā)生發(fā)展過程中發(fā)揮重要作用,增加心血管疾病發(fā)生風(fēng)險。
[Abstract]:Objective: to investigate the relationship between Helicobacter pylori (HP) infection and coronary atherosclerotic heart disease (CHDD) in Dali population, and to explore the relationship between HP infection and blood lipid in CHD patients. The relationship between homocysteine homocysteine, Hcyn, high sensitivity c-reactive protein hs-CRPN, cystatin Cystatin CysCand the relationship between different Helicobacter pylori strains and coronary heart disease was studied, which provided a theoretical basis for the diagnosis and treatment of coronary heart disease. Methods: according to the results of coronary angiography, 122 patients with coronary heart disease were divided into HP infection group (n = 82) and non-HP infection group (n = 40) from January 2016 to December 2016. The 837 patients were divided into two groups: 278 cases of HP positive infection and 559 cases of HP negative. All the patients were tested for the serum lipids Hcyhs-CRPU CysC and so on. The data were processed by SPSS 17.0 software. The data were expressed as x 鹵s, t-test was used in the comparison between groups, chi-square test was used in the comparison of counting data, and the difference was statistically significant with P0.05. Multiple Logistic regression analysis was used to analyze the risk factors of coronary heart disease (CHD). Results: the total infection rate of Helicobacter pylori was 33.21, the infection rate of male was 35.06 and the infection rate of female was 30.93.122 cases of CHD. The serum Hcy concentration of 82 patients with HP infection was significantly higher than that of non-infection group. In patients with coronary heart disease (CHD), the level of Hcyn Cys CysCnhs-CRPnTGP LDL in HP infection group was significantly higher than that in HP infection negative group. The levels of plasma HCY and hs-CRP in patients with HP type 鈪，

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