發(fā)布時間：2018-04-22 02:04

  本文選題：慢性阻塞性肺疾病 + 肺動脈高壓��； 參考：《山東醫(yī)藥》2017年01期

【摘要】：目的探討炎癥反應(yīng)與慢性阻塞性肺疾病(COPD)相關(guān)肺動脈高壓及其高凝狀態(tài)的關(guān)系。方法收集COPD患者80例,根據(jù)心臟超聲估測肺動脈收縮壓(PASP),以PASP 40 mm Hg為界將患者分為COPD伴肺動脈高壓組和COPD無肺動脈高壓組兩組(每組40例),檢測兩組血清C反應(yīng)蛋白(CRP)、白介素6(IL-6)、白介素8(IL-8)、腫瘤壞死因子-α(TNF-α)、腦鈉肽(BNP)、D-二聚體(D-D)、纖維蛋白原(FIB)、紅細胞壓積(HCT),比較兩組各項檢測的差異,分析炎性因子與肺動脈壓、D-D的相關(guān)性以及肺動脈高壓、高凝狀態(tài)的影響因素。結(jié)果肺動脈高壓組血清CRP、IL-6、IL-8、TNF-α、D-D、FIB、BNP水平高于無肺動脈高壓組(P均0.05)。偏相關(guān)性分析顯示,CRP、IL-6、IL-8水平與PASP呈正相關(guān),Pa O2與PASP呈負相關(guān)(r分別為0.387、0.611、0.412、-0.576,P均0.05),CRP水平與D-D呈正相關(guān)(r=0.379,P0.05)。二元Logistic回歸分析示,CRP、IL-8、TNF-α為肺動脈高壓的危險因素;Pa O2為其保護因素;CRP、IL-6為血液高凝狀態(tài)的危險因素。結(jié)論炎癥反應(yīng)及其炎癥因子對COPD相關(guān)肺動脈高壓及其血液高凝狀態(tài)形成有重要作用。
[Abstract]:Objective to investigate the relationship between inflammatory response and pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD) and its hypercoagulability. Methods 80 patients with COPD were collected. The patients were divided into two groups: COPD with pulmonary hypertension and COPD without pulmonary hypertension (40 cases in each group). The serum C-reactive protein (CRP), interleukin-6 (IL-6) IL-6 and white medium were detected in the two groups according to echocardiographic estimation of pulmonary arterial systolic blood pressure (PAP). TNF- 偽, TNF- 偽, BNP, FIBB, HCT and HCT were compared between the two groups. To analyze the correlation between inflammatory factors and pulmonary artery pressure D-D, and the influencing factors of pulmonary hypertension and hypercoagulability. Results the serum levels of TNF- 偽 D and FIBN BNP in patients with pulmonary hypertension were higher than those in patients without pulmonary hypertension (P < 0.05). The partial correlation analysis showed that the level of IL-6 IL-8 was positively correlated with PASP, and there was a negative correlation between PASP and Pao _ 2, r was 0.387V 0.6110.412 ~ -0.576p, respectively, and there was a positive correlation between IL-8 level and D-D, 0.379m P0.05a. Binary Logistic regression analysis showed that IL-8 TNF- 偽 was the risk factor of pulmonary hypertension and PAO _ 2 was its protective factor and IL-6 was the risk factor of hypercoagulability. Conclusion inflammatory reaction and its inflammatory factors play an important role in the formation of COPD associated pulmonary hypertension and hypercoagulability.
【作者單位】： 武漢市中心醫(yī)院;武漢大學(xué)人民醫(yī)院;
【分類號】：R563.9;R544.1

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