本文選題：高血壓 + 免疫球蛋白G��； 參考：《中國(guó)全科醫(yī)學(xué)》2017年05期

【摘要】：目的分析新疆哈薩克族人群高血壓與血漿免疫球蛋白G(Ig G)N-糖基組的關(guān)聯(lián),尋找高血壓疾病狀態(tài)的潛在分子標(biāo)志物。方法采用簡(jiǎn)單隨機(jī)抽樣,選取2014年2—6月于新疆伊犁哈薩克自治州瓊博拉鄉(xiāng)衛(wèi)生院建立健康檔案的哈薩克族居民92例為研究對(duì)象,根據(jù)高血壓診斷標(biāo)準(zhǔn),將研究對(duì)象分為血壓正常組(n=35)、正常高值組(n=27)和高血壓組(n=30)。采用液相色譜-電噴霧質(zhì)譜聯(lián)用技術(shù)檢測(cè)血漿Ig G N-糖基組。結(jié)果每例受試者的各Ig G亞型均檢測(cè)到G0、G0F、G0FN、G0N、G1、G1F、G1FN、G1FNS、G1FS、G1N、G1NS、G1S、G2、G2F、G2FN、G2FNS、G2FS、G2N、G2NS、G2S等20種聚糖結(jié)構(gòu)。除G0外,不同Ig G亞型各N-聚糖水平比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。高血壓組Ig G1亞型G0F、G0FN、G1FS水平高于血壓正常組,G2、G2FS水平低于血壓正常組;正常高值組Ig G1亞型G2F水平低于血壓正常組,高血壓組Ig G1亞型G2F水平低于血壓正常組、正常高值組(P0.05)。正常高值組Ig G2/3亞型G0FN、G0N水平高于血壓正常組,G2、G2S水平低于血壓正常組;高血壓組Ig G2/3亞型G0、G0F、G0FN、G0N水平高于血壓正常組,G2、G2F、G2FS、G2NS、G2S水平低于血壓正常組,G2FN、G2FNS水平低于血壓正常組、正常高值組(P0.05)。高血壓組Ig G4亞型G0FN水平高于血壓正常組、正常高值組(P0.05)。正常高值組Ig G1亞型半乳糖基化水平低于血壓正常組,高血壓組Ig G1亞型半乳糖基化水平低于血壓正常組和正常高值組(P0.05)。正常高值組、高血壓組Ig G2/3亞型半乳糖基化、唾液酸化水平低于血壓正常組,高血壓組Ig G2/3亞型半乳糖基化水平低于正常高值組(P0.05)。結(jié)論新疆哈薩克族人群不同血壓狀態(tài)與其血漿Ig G N-糖基組譜型變化相關(guān),Ig G1亞型G2F水平及Ig G1、Ig G2/3亞型半乳糖基化水平的改變可能是該人群高血壓疾病狀態(tài)潛在的早期預(yù)警分子標(biāo)志物和治療新靶點(diǎn)。
[Abstract]:Objective to analyze the association between hypertension and plasma immunoglobulin (G(Ig) N-glycosyl group in Kazakh people in Xinjiang, and to find out the potential molecular markers of hypertension. Methods A total of 92 Kazakh residents who established a health file in Qiongbora Health Center in Yili Kazakh Autonomous Prefecture, Xinjiang, from February to June 2014, were selected as the study objects. According to the diagnostic criteria of hypertension, 92 Kazakh residents were selected as the subjects of the study. The subjects were divided into two groups: normal blood pressure group (n = 35), normal high value group (n = 27) and hypertension group (n = 30). Plasma Ig-N-glycosyl group was determined by liquid chromatography-electrospray-mass spectrometry. Results 20 kinds of glycan structures, such as G _ (1) F _ (1) G _ (1F) G _ (1F) G _ (1FN) G _ (1FN) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (1) G _ (2) G _ (2) G _ (2) G _ (2) G _ (2) G _ (2) G _ (2) G _ (2) G _ (2) G _ (2) G _ With the exception of G0, the levels of N- glycan in different Ig G subtypes were significantly different (P 0.05). The level of G _ 1FS of G _ 1 subtype G _ 0FN _ 1FS in hypertension group was higher than that in normal blood pressure group, the level of G _ (2) F in normal group was lower than that in normal blood pressure group, the level of G _ (2) F in normal high value group was lower than that in normal blood pressure group, and the level of G _ (2) F in hypertension group was lower than that in normal blood pressure group (P < 0.05). The level of Ig G 4 subtype G0FN in hypertension group was higher than that in normal blood pressure group (P 0.05). The level of galactosylation in normal high value group was lower than that in normal blood pressure group, and the level of Ig G1 subtype galactosylation in hypertension group was lower than that in normal blood pressure group and normal high value group (P 0.05). The level of gG _ 2 / 3 subtype galactosylation and salivary acidification in hypertension group was lower than that in normal blood pressure group, and the level of IGG _ 2 / 3 subtype galactosylation in hypertension group was lower than that in normal high value group (P 0.05). Conclusion the changes of blood pressure status and plasma Ig G N- glycosylation patterns in Kazak population in Xinjiang are related to the changes of G 2F level in plasma Ig G 1 subtype and galactosylation level of IgG G 2 / 3 subtype Ig G 1 G 2 / 3 subtype in Xinjiang Kazak population, which may be the potential status of hypertension in this population. Early warning molecular markers and new therapeutic targets.
【作者單位】： 首都醫(yī)科大學(xué)公共衛(wèi)生學(xué)院;臨床流行病學(xué)北京市重點(diǎn)實(shí)驗(yàn)室;新疆大學(xué)生命科學(xué)與技術(shù)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(81573215) 北京市屬高等學(xué)校青年拔尖人才培育計(jì)劃項(xiàng)目(CIT&TCD201404185)
【分類號(hào)】：R544.1

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