本文選題：心力衰竭 + 心臟再同步化治療��； 參考：《重慶醫(yī)學(xué)》2017年25期

【摘要】：目的研究失同步化缺血性心力衰竭在左心室內(nèi)膜起搏下心電生理的變化。方法應(yīng)用左束支射頻消融術(shù)和冠狀動(dòng)脈前降支結(jié)扎術(shù)建立18只健康犬缺血性心力衰竭模型。使用隨機(jī)數(shù)字表法對(duì)18只健康犬進(jìn)行分組,每組各9只。實(shí)驗(yàn)組行左心室內(nèi)膜心臟再同步化治療(CRT),對(duì)照組行假手術(shù),術(shù)后6周檢查心電圖、超聲心動(dòng)圖。結(jié)果實(shí)驗(yàn)組左室射血分?jǐn)?shù)明顯高于對(duì)照組(38.32±6.08 vs.30.62±8.96),失同步化指數(shù)顯著低于對(duì)照組(35.99±5.25 vs.78.21±7.02),差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。實(shí)驗(yàn)組QRS(60.58±7.43 vs.68.33±8.01)、QTc(347.09±17.33 vs.367.81±22.02)均顯著短于對(duì)照組(均P0.05);且Tp-e(37.03±9.07 vs.45.76±7.11)、ARI(162.33±22.06 vs.187.21±23.87)均明顯少于對(duì)照組(均P0.05)。結(jié)論左心室內(nèi)膜起搏可以產(chǎn)生較好的電生理效應(yīng),達(dá)到有效的心臟再同步治療目的。
[Abstract]:Objective To study the changes of cardiac electrophysiology in left ventricular endocardial pacing by using left bundle branch radiofrequency ablation and anterior descending coronary artery ligation in 18 healthy dogs . The results showed that the left ventricular ejection fraction of experimental group was significantly higher than that in the control group ( 38.32 鹵 6.08 vs . 68.33 鹵 8.96 ) . The results showed that the left ventricular ejection fraction of experimental group was significantly lower than that in the control group ( P < 0.05 ) .

【作者單位】： 唐山工人醫(yī)院心內(nèi)一科;中國(guó)醫(yī)學(xué)科學(xué)院阜外心血管病醫(yī)院心內(nèi)科;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(81200135)
【分類號(hào)】：R541.6

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