本文選題：糖尿病心肌病　切入點(diǎn)：NADPH氧化酶　出處：《中國病理生理雜志》2017年07期

【摘要】：目的:觀察鏈脲佐菌素誘導(dǎo)的糖尿病大鼠心肌組織中NADPH氧化酶表達(dá)的變化,探討運(yùn)動對NADPH氧化酶的影響。方法:大鼠糖尿病模型建立成功1周后,測定糖尿病對心肌組織中NADPH氧化酶亞基表達(dá)的影響,測定8周的運(yùn)動能否有效影響NADPH氧化酶亞基的表達(dá);觀測糖尿病對心肌膠原蛋白表達(dá)的影響,8周運(yùn)動是否能夠影響膠原蛋白的表達(dá)。結(jié)果:糖尿病導(dǎo)致心室NADPH氧化酶亞基p47~(phox)和gp91~(phox)表達(dá)增加,而8周運(yùn)動能夠抑制這2種亞基表達(dá)的增加;糖尿病引起心房肌p47~(phox)表達(dá)顯著增加,運(yùn)動抑制其增加;糖尿病大鼠心肌膠原蛋白Ⅲ水平顯著增加,運(yùn)動降低膠原蛋白的增加。結(jié)論:運(yùn)動減低糖尿病大鼠心臟p47~(phox)和gp91~(phox)的表達(dá)。這可能是改善心內(nèi)基質(zhì)的重要機(jī)制,因此運(yùn)動干預(yù)糖尿病心肌病的一個有效機(jī)制可能是通過抑制心肌氧化應(yīng)激和降低膠原蛋白的表達(dá)。
[Abstract]:Aim: to observe the changes of NADPH oxidase expression in myocardium of streptozotocin induced diabetic rats and to explore the effect of exercise on NADPH oxidase.Methods: the effects of diabetes on the expression of NADPH oxidase subunits in myocardial tissue were measured one week after the establishment of diabetic model in rats, and the effects of exercise at 8 weeks on the expression of NADPH oxidase subunits were determined.The effect of diabetes on myocardial collagen expression was observed.Results: the expression of NADPH oxidase subunit (p47) and gp91trophox) were increased by diabetes mellitus, but the expression of these two subunits was inhibited by exercise for 8 weeks, and the expression of p47 moxiphox in atrial muscle was significantly increased after exercise for 8 weeks, and the increase was inhibited by exercise.Myocardial collagen 鈪，

本文編號：1701901