本文選題：他汀　切入點：基因多態(tài)性　出處：《首都醫(yī)科大學》2017年碩士論文

【摘要】：目的探索我國冠心病患者中APOE、ABCB1基因多態(tài)性與阿托伐他汀調脂效果的關聯(lián)性。方法回顧性篩選2014.12-2016.7之間應用阿托伐他汀20mg/d并進行APOE、ABCB1 G2677T/A(rs2032582)、ABCB1 C3435T(rs1045642)基因檢測的冠心病患者162例,按APOE、ABCB1基因型分別分為野生基因組和突變基因組。比較各組患者基線和治療4周后甘油三酯、總膽固醇、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇水平及變化的差異,分析APOE、ABCB1基因多態(tài)性與阿托伐他汀調脂效果的關聯(lián)性。結果APOEε4基因攜帶組基線低密度脂蛋白膽固醇水平顯著高于ε3/ε3型組與ε2基因攜帶組(P=0.008);ε4基因攜帶者應用阿托伐他汀治療后總膽固醇與低密度脂蛋白膽固醇水平顯著高于ε3/ε3型患者和ε2基因攜帶者(P=0.012,P=0.010)APOEε2基因攜帶組、ε3/ε3型組、ε4基因攜帶組三組間甘油三酯、總膽固醇、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇變化率無顯著性差異(P0.05);ABCB1 G2677T/A、ABCB1 C3435T野生純合組、突變雜合組、突變純合組間基線甘油三酯、總膽固醇、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇水平,以及甘油三酯、總膽固醇、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇變化率均無顯著性差異(P0.05)。結論APOEε4等位基因與低密度脂蛋白膽固醇水平升高相關。APOE基因多態(tài)性可能與阿托伐他汀治療后總膽固醇水平有關。APOE基因多態(tài)性與應用阿托伐他汀前后甘油三酯、總膽固醇、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇變化率無關。ABCB1 G2677T/A、ABCB1 C3435T基因多態(tài)性與患者基線甘油三酯、總膽固醇、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇水平以及應用阿托伐他汀前后甘油三酯、總膽固醇、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇變化率無關。
[Abstract]:Objective to explore the association between APOEA ABCB1 gene polymorphism and the effect of Atto vastatin on lipid regulation in Chinese patients with coronary heart disease.The levels and changes of triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol were compared between baseline and 4 weeks after treatment, and the association between APOEO ABCB1 gene polymorphism and the effect of Atto vastatin on lipid regulation was analyzed.Results the baseline low density lipoprotein cholesterol level in APOE 蔚 4 gene carrying group was significantly higher than that in 蔚 3 / 蔚 3 type group and 蔚 2 gene carrying group, and the total cholesterol and low density lipoprotein cholesterol levels in 蔚 4 gene carriers were significantly higher than those in 蔚 3 / 蔚 3 and 蔚 2 gene carriers treated with Atto vastatin.In the patients with 蔚 3 / 蔚 3 type and the carriers of 蔚 2 gene, there were three groups of triglyceride, the group of 蔚 3 / 蔚 3, the group of carrying 蔚 2 gene, the group of 蔚 3 / 蔚 3, the group of 蔚 2 gene carrying.There was no significant difference in the levels of high density lipoprotein cholesterol, triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol.Conclusion the allele of APOE 蔚 4 is associated with the elevation of low density lipoprotein cholesterol. APOE gene polymorphism may be related to the total cholesterol level after Atto vastatin therapy and to triglyceride and total cholesterol before and after Atto vastatin therapy.Low density lipoprotein cholesterol, high density lipoprotein cholesterol change rate. ABCB1 G2677T / AhABCB1 C3435T gene polymorphism and baseline triglyceride, total cholesterol, low density lipoprotein cholesterol,High density lipoprotein cholesterol level, triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol were not related to the changes of triglyceride, total cholesterol and high density lipoprotein cholesterol before and after the treatment of Atto vastatin.
【學位授予單位】：首都醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R541.4

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本文編號：1695280