本文選題：急性高血壓腦出血　切入點：CXCL　出處：《國際神經(jīng)病學(xué)神經(jīng)外科學(xué)雜志》2017年03期 　論文類型：期刊論文

【摘要】：目的探討急性高血壓腦出血患者血漿CXCL12水平的動態(tài)變化及其對預(yù)后的影響,以及血漿CXCL12水平與相對水腫體積的關(guān)系。方法選擇急性高血壓腦出血患者34例,于發(fā)病24小時內(nèi)、第3天、第7天和第14天采用ELISA法檢測血漿CXCL12水平,選擇同期25例健康體檢者作為對照組。根據(jù)mRS評分將腦出血患者分為預(yù)后良好組(mRS≤2分)和預(yù)后不良組(mRS2分)。于發(fā)病24小時內(nèi)、第3天和第7天根據(jù)顱腦CT計算相對水腫體積。結(jié)果腦出血組24小時內(nèi)血漿CXCL12水平(19.85±1.84)μg/L明顯高于對照組(11.34±2.23)μg/L,P0.01。腦出血組血漿CXCL12水平在第3天時快速上升(22.56±1.56)μg/L,在第7天達高峰(23.38±1.53)μg/L,在第14天時下降(22.64±1.78)μg/L。預(yù)后良好組與整體的變化趨勢一致,預(yù)后不良組血漿CXCL12水平在第14天時未見下降;兩組血漿CXCL12水平在第7天時和第14天時比較差異均有統(tǒng)計學(xué)意義,P值分別為0.05和0.01。Pearson相關(guān)性分析顯示第3天和第7天血漿CXCL12水平與相對水腫體積呈正相關(guān),相關(guān)系數(shù)分別為(r=0.631,P0.01)和(r=0.435,P0.05)。結(jié)論血漿CXCL12水平在腦出血后明顯升高,持續(xù)性CXCL12水平升高的患者預(yù)后較差。動態(tài)檢測血漿CXCL12水平能夠為腦水腫的評估和治療提供依據(jù)。
[Abstract]:Objective to investigate the dynamic changes of plasma CXCL12 level and its influence on prognosis in patients with acute hypertensive intracerebral hemorrhage and the relationship between plasma CXCL12 level and relative edema volume. Methods 34 patients with acute hypertensive intracerebral hemorrhage were selected within 24 hours after onset. On day 3, day 7 and day 14, plasma CXCL12 levels were measured by ELISA assay. 25 healthy persons were selected as control group. According to mRS score, the patients with ICH were divided into two groups: good prognosis group (MRs 鈮，

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