本文選題：高尿酸血癥　切入點(diǎn)：冠心病　出處：《山西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:初步探究高尿酸血癥與冠心病的關(guān)系。方法:選取山西省心血管病醫(yī)院200例高尿酸血癥患者。通過冠脈造影確診為冠心病的設(shè)為觀察組,人數(shù)為123例,平均年齡為(60.98±10.19)歲;冠脈造影結(jié)果正常的設(shè)為對照組,人數(shù)為77例,平均年齡為(60.03±9.64)歲。對兩組血尿酸、肌酐、尿素氮、甘油三脂、總膽固醇、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇等生化指標(biāo)進(jìn)行比較。結(jié)果:兩組的性別、年齡、糖尿病史、吸煙史、飲酒史無統(tǒng)計學(xué)差異(P0.05);高血壓病史、血脂異常病史有統(tǒng)計學(xué)差異(P0.05)。兩組的血尿酸、總膽固醇、低密度脂蛋白膽固醇有差異(P0.05)。兩組logistic回歸分析顯示:高尿酸血癥、總膽固醇是冠心病的獨(dú)立危險因素(P0.05)。血尿酸與總膽固醇、低密度脂蛋白膽固醇、體重指數(shù)、空腹血糖、甘油三酯、呈正相關(guān)性,與高密度脂蛋白膽固醇呈負(fù)相關(guān)性。結(jié)論:高尿酸血癥、總膽固醇是冠心病的獨(dú)立危險因素,血尿酸、總膽固醇的水平越高,冠心病的發(fā)病率、死亡率越高。降低血尿酸、總膽固醇水平,有利于降低冠心病的發(fā)病率、死亡率。血尿酸與總膽固醇、低密度脂蛋白膽固醇、體重指數(shù)、空腹血糖、甘油三酯呈正相關(guān)性,與高密度脂蛋白膽固醇呈負(fù)相關(guān)性。降低總膽固醇、低密度脂蛋白膽固醇、體重指數(shù)、空腹血糖、甘油三酯或提高高密度脂蛋白膽固醇的水平,有利于血尿酸水平的控制。
[Abstract]:Objective: to explore the relationship between hyperuricemia and coronary heart disease (CHD). Methods: 200 patients with hyperuricemia in Shanxi Cardiovascular Disease Hospital were selected as observation group, 123 patients were diagnosed by coronary angiography, the average age was 60.98 鹵10.19 years. The normal coronary angiography results were used as control group (77 cases, mean age: 60.03 鹵9.64) years. Serum uric acid, creatinine, urea nitrogen, triglyceride, total cholesterol, high density lipoprotein cholesterol (HDL-C) were measured in two groups. Results: there was no significant difference in sex, age, history of diabetes, history of smoking, history of alcohol consumption between the two groups (P 0.05), and there were significant differences in the history of hypertension and dyslipidemia between the two groups (P 0.05). Logistic regression analysis showed that hyperuricemia and total cholesterol were the independent risk factors for coronary heart disease (CHD). Serum uric acid and total cholesterol, low density lipoprotein cholesterol, body mass index (BMI). Fasting blood glucose, triglyceride, positive correlation, and high density lipoprotein cholesterol negative correlation. Conclusion: hyperuricemia, total cholesterol is an independent risk factor for coronary heart disease, the higher the level of serum uric acid, total cholesterol, The higher the incidence of coronary heart disease, the higher the mortality. Lowering the level of serum uric acid and total cholesterol is conducive to reducing the incidence and mortality of coronary heart disease. Serum uric acid and total cholesterol, low density lipoprotein cholesterol, body mass index, fasting blood glucose, There was a positive correlation between triglycerides and high density lipoprotein cholesterol (HDL-C). Decrease in total cholesterol, low density lipoprotein cholesterol, body mass index, fasting blood glucose, triglyceride or elevated HDL cholesterol levels, It is beneficial to the control of serum uric acid level.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R541.4;R589.7

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 牛洪梅;;高尿酸血癥對冠心病診斷價值的研究[J];中國現(xiàn)代藥物應(yīng)用;2016年06期

2 關(guān)寶生;王艷秋;白雪;周憲君;尹相林;展秀君;沈萍;王緣;邱洪斌;;高尿酸血癥的危險因素[J];中國老年學(xué)雜志;2016年01期

3 毛琳;;南海農(nóng)村地區(qū)血尿酸水平及干預(yù)治療對冠心病影響的前瞻性研究[J];中國現(xiàn)代醫(yī)生;2015年23期

4 平凡;晏婷婷;汪悅;;尿酸在腸道代謝機(jī)制中的研究進(jìn)展[J];醫(yī)學(xué)研究生學(xué)報;2015年07期

5 呂秀芹;;262例男性高尿酸血癥與冠心病的關(guān)系分析[J];寧夏醫(yī)學(xué)雜志;2014年04期

6 Bibek Poudel;Binod Kumar Yadav;Arun Kumar;Bharat Jha;Kanak Bahadur Raut;;Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population:A hospital based cross sectional study[J];Asian Pacific Journal of Tropical Biomedicine;2014年01期

7 吳永輝;史哲;吳立華;;不穩(wěn)定型心絞痛合并高尿酸血癥患者內(nèi)皮功能的研究[J];中西醫(yī)結(jié)合心腦血管病雜志;2013年09期

8 陳濤;李衛(wèi);王楊;胡泊;徐濤;劉冰;孫毅;;高尿酸血癥的患病情況及相關(guān)因素分析[J];中華臨床醫(yī)師雜志(電子版);2012年13期

9 丁海峰;馬蘭;范鷹;;高血壓病合并高尿酸血癥與冠心病的關(guān)系[J];中國動脈硬化雜志;2011年04期

10 唱麗敏;劉月秋;王金俠;孔麗清;;高尿酸血癥與冠心病相關(guān)性分析[J];中國誤診學(xué)雜志;2010年16期

，

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