本文選題：心肌梗死　切入點(diǎn)：致癌抑制因子　出處：《中國(guó)循環(huán)雜志》2017年01期 　論文類型：期刊論文

【摘要】：目的:本研究初步探討基線可溶性致癌抑制因子2(sST2)水平與急性ST段抬高型心肌梗死(STEMI)患者30 d主要不良心血管事件(MACE)發(fā)生的關(guān)系。方法:連續(xù)入組2015-05-01至2015-07-30期間就診我院并明確診斷STEMI患者121例。依據(jù)基線sST2中位數(shù)水平分為sST2低值組(sST2≤56.68 ng/ml,n=61)、sST2高值組(sST256.68 ng/ml,n=60)。比較兩組患者的臨床資料及30 d的MACE(定義為死亡、新發(fā)慢性心力衰竭)發(fā)生率。結(jié)果:(1)兩組在收縮壓、Killip心功能分級(jí)≥Ⅱ級(jí)、血清肌鈣蛋白I峰值、N末端B型利鈉肽原(NT-pro BNP)、超敏C反應(yīng)蛋白(hs-CRP)、左心室射血分?jǐn)?shù)(LVEF)等方面差異均有統(tǒng)計(jì)學(xué)意義(P均0.05)。(2)基線sST2水平與心率(r=0.271,P=0.003)、hs-CRP(r=0.359,P=0.000)、肌鈣蛋白I(r=0.324,P=0.000)及NT-pro BNP(r=0.425,P=0.000)均呈正相關(guān);與收縮壓(r=-0.226,P=0.013)及LVEF(r=-0.406,P=0.000)均呈負(fù)相關(guān)。(3)sST2低值組MACE發(fā)生率(8.2%)低于sST2高值組(30%),差異有統(tǒng)計(jì)學(xué)意義(P=0.002)。(4)多因素Cox回歸分析顯示sST256.68 ng/ml是STEMI患者30 d出現(xiàn)MACE的危險(xiǎn)因素(危險(xiǎn)比=1.152,95%可信區(qū)間:1.078~1.231,P=0.000)。結(jié)論:STEMI患者基線sST2水平升高提示近期死亡及新發(fā)心力衰竭風(fēng)險(xiǎn)增加。
[Abstract]:Objective: to investigate the relationship between baseline soluble carcinogenic suppressor 2s ST2 (sST2) and the occurrence of major adverse cardiovascular events (MACEE) in patients with acute ST-segment elevation myocardial infarction (STEMI) after 30 days of acute ST-segment elevation myocardial infarction (STEMI). Methods: from 2015-05-01 to 2015-07-30, the main adverse cardiovascular events occurred in patients with acute ST-segment elevation myocardial infarction. 121 cases of STEMI were diagnosed and diagnosed in our hospital. According to the median level of baseline sST2, they were divided into two groups: sST2 low value group was divided into sST2 low value group (S ST2 鈮，

本文編號(hào)：1605202