本文選題：急性心肌梗死　切入點：Toll樣受體-　出處：《山東醫(yī)藥》2017年17期 　論文類型：期刊論文

【摘要】：目的探討Toll樣受體-4(TLR4)基因多態(tài)性與急性心肌梗死(AMI)發(fā)病風險的關系。方法選取AMI患者244例(AMI組)和非AMI患者284例(對照組),采用聚合酶鏈反應-限制性片段長度多態(tài)性技術檢測兩組TLR4基因啟動子區(qū)多態(tài)性(rs10116253和rs10983755),比較兩組TLR4啟動子區(qū)多態(tài)性的基因型分布差異,采用多因素Logistic回歸模型分析TLR4基因啟動子區(qū)多態(tài)性與AMI發(fā)病風險的關系。結果TLR4基因rs10116253、rs10983755均符合Hardy-Weiberg平衡。TLR4啟動子區(qū)rs10116253和rs10983755多態(tài)性與AMI的總體發(fā)病風險無關(P均0.05)。對于TLR4基因rs10116253多態(tài)位點,男性TC突變雜合型攜帶者AMI的發(fā)病風險是TT野生純合型攜帶者的0.50倍,TC+CC突變型攜帶者AMI發(fā)病風險是TT野生純合型攜帶者的0.51倍,伴有高血脂的TC雜合型攜帶者AMI發(fā)病風險是TT野生純合型攜帶者的0.42倍,TC+CC突變型攜帶者AMI發(fā)病風險是TT野生純合型攜帶者的0.46倍,差異均有統(tǒng)計學意義(P均0.05)。TLR4基因rs10983755多態(tài)位點在性別、年齡、有無高血壓、有無糖尿病及有無血脂異常等分層分析中均未見統(tǒng)計學差異(P均0.05)。結論TLR4基因啟動子區(qū)rs10116253多態(tài)性與AMI分層發(fā)病風險存在關系;rs10116253突變基因型可以降低男性人群、伴有高血脂人群AMI的發(fā)病風險。
[Abstract]:Objective to investigate the relationship between the polymorphism of Toll like receptor -4 (TLR4) gene and the risk of acute myocardial infarction (AMI). Methods 244 AMI patients and 284 non-AMI patients (control group) were studied by polymerase chain reaction-restriction fragment length (PCR). The polymorphism of TLR4 gene promoter region rs10116253 and rs10983755 was detected by polymorphic technique, and the genotype distribution of TLR4 promoter polymorphism was compared between the two groups. Multivariate Logistic regression model was used to analyze the relationship between the polymorphism of TLR4 gene promoter region and the risk of AMI. Results TLR4 gene rs10116253 rs10983755 all accord with Hardy-Weiberg balance. Rs10116253 and rs10983755 polymorphism of TLR4 promoter region were not correlated with the overall risk of AMI (P < 0.05). At the rs10116253 polymorphic site of TLR4 gene, The risk of AMI in male carriers with TC mutation was 0.50 times as high as that of carriers with TT wild homozygote. The risk of AMI in carriers with TC CC mutation was 0.51 times higher than that of carriers with wild heterozygous type of TT. The risk of AMI in TC heterozygous carriers with hyperlipidemia was 0.42 times higher than that in TT wild homozygous carriers. The AMI risk of TC CC mutant carriers was 0.46 times higher than that of TT wild homozygous carriers. The differences were statistically significant (P < 0.05). The rs10983755 polymorphism of TLR4 gene was in sex, age, hypertension or not. There was no statistical difference in the stratified analysis of diabetes mellitus and dyslipidemia (P < 0.05). Conclusion there is a relationship between the rs10116253 polymorphism of TLR4 gene promoter region and the risk of AMI stratification. The mutation genotype rs10116253 can reduce the male population. Risk of AMI associated with hyperlipidemia.
【作者單位】： 中國醫(yī)科大學附屬第一醫(yī)院;
【基金】：遼寧省自然科學基金計劃項目(2015020506)
【分類號】：R542.22

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