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個(gè)體化運(yùn)動(dòng)有效治療高血壓的研究及逐搏血壓監(jiān)測在臨床中的應(yīng)用

發(fā)布時(shí)間:2018-02-26 16:34

  本文關(guān)鍵詞: 高血壓 心肺運(yùn)動(dòng)試驗(yàn) 個(gè)體化適度強(qiáng)度運(yùn)動(dòng) 整體治療方案 有效治療 連續(xù)無創(chuàng)逐搏血壓 心肺運(yùn)動(dòng)試驗(yàn) 運(yùn)動(dòng)試驗(yàn)停止指征 出處:《北京協(xié)和醫(yī)學(xué)院》2017年碩士論文 論文類型:學(xué)位論文


【摘要】:目的:運(yùn)用心肺運(yùn)動(dòng)試驗(yàn)(cardiopulmonary exercise testing,CPET)對(duì)患者進(jìn)行客觀定量整體功能評(píng)估,精準(zhǔn)制定個(gè)體化適度強(qiáng)度運(yùn)動(dòng)整體治療方案,以有效治療高血壓。方法:選擇5例應(yīng)用藥物治療穩(wěn)定的高血壓患者進(jìn)行癥狀限制性CPET檢查,以CPET結(jié)果為依據(jù)進(jìn)行計(jì)算分析,進(jìn)而精準(zhǔn)地制定介于無氧閡和峰值功率之間的個(gè)體化適度強(qiáng)度負(fù)荷功率的運(yùn)動(dòng)處方,配合多種輔助運(yùn)動(dòng)、精神心理方面、勞逸結(jié)合、睡眠管理、禁煙限酒、健康飲食生活習(xí)慣及優(yōu)化藥物等形成整體方案。堅(jiān)持每天強(qiáng)化運(yùn)動(dòng)一次、每周5天,共計(jì)12周,每天測定患者運(yùn)動(dòng)前、后的血壓,運(yùn)動(dòng)中連續(xù)監(jiān)測血壓、心電圖、心率和氧飽和度,期間根據(jù)血壓穩(wěn)定程度調(diào)整藥物。將運(yùn)動(dòng)前、后和第1、12周血壓的變化進(jìn)行自身對(duì)照統(tǒng)計(jì)分析。結(jié)果:高血壓患者運(yùn)動(dòng)治療前均服用至少一種降壓藥物,運(yùn)動(dòng)治療2~6周后全部停用降壓藥物。患者運(yùn)動(dòng)后收縮壓(systolicblood pressure,SBP)[運(yùn)動(dòng)前(125±11)mmHg與運(yùn)動(dòng)后(116±10)mm Hg]、舒張壓(diastolic blood pressure,DBP)[運(yùn)動(dòng)前(74±8)mm Hg與運(yùn)動(dòng)后(71±7)mmHg]均較運(yùn)動(dòng)前顯著降低(P0.05)。雖然第12周時(shí)已經(jīng)減、停用抗高血壓藥物6周以上,運(yùn)動(dòng)前靜息SBP仍較第1周(使用藥物時(shí))顯著降低[第1周(127±8)m Hg與第12周(121±9)m Hg](P0.05);第1周與第12周運(yùn)動(dòng)后靜息SBP、運(yùn)動(dòng)前后靜息DBP比較均無統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論:本研究運(yùn)用CPET客觀定量評(píng)估指導(dǎo)的精準(zhǔn)制訂個(gè)體化適度強(qiáng)度運(yùn)動(dòng)為核心的整體方案,可以使高血壓病患者獲得驚人的降壓效果,并且停藥后仍然能夠維持血壓穩(wěn)定。值得進(jìn)一步擴(kuò)大病例深入研究。目的:通過無創(chuàng)方法監(jiān)測心肺運(yùn)動(dòng)試驗(yàn)(cardiopulmonary exercise testing,CPET)過程中的逐搏血壓,同時(shí)與傳統(tǒng)的袖帶間斷測壓相比較,重點(diǎn)觀察心肺運(yùn)動(dòng)試驗(yàn)過程中的最高血壓值,以探討定量的血壓值是否能夠作為終止心肺運(yùn)動(dòng)試驗(yàn)指征。方法:選擇2016年8-10月份在阜外醫(yī)院進(jìn)行CPET的健康志愿者6例,在常規(guī)的心肺運(yùn)動(dòng)試驗(yàn)中佩戴連續(xù)無創(chuàng)逐搏血壓監(jiān)測儀器。對(duì)不同階段的袖帶間斷測壓與連續(xù)逐搏血壓值進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:在心肺運(yùn)動(dòng)試驗(yàn)過程中6位志愿者中有兩位的最高血壓超過了 250mmHg,而袖帶間斷測壓檢測到的最高血壓僅為187mmHg。收縮壓在熱身期以及恢復(fù)期5分鐘有統(tǒng)計(jì)學(xué)差異(p0.05),其他時(shí)期無統(tǒng)計(jì)學(xué)差異;舒張壓在恢復(fù)期2分鐘及恢復(fù)期5分鐘有統(tǒng)計(jì)學(xué)差異(pp0.05),其他時(shí)期無統(tǒng)計(jì)學(xué)差異。結(jié)論:連續(xù)逐搏血壓可更好的反映CPET中的血壓連續(xù)狀態(tài)以及極限值。在癥狀限制性的CPET中,并不能完全以某一特定的最高血壓值作為參考作為終止心肺運(yùn)動(dòng)試驗(yàn)的指標(biāo)。
[Abstract]:Objective: to evaluate the overall function of patients with cardiopulmonary exercise test by using cardiopulmonary exercise test (CPET), and to formulate the individual moderate intensity exercise therapy accurately. Methods: five patients with stable hypertension who were treated with drugs were selected for symptomatic restricted CPET examination. The results of CPET were calculated and analyzed. And then make the exercise prescription of the individualized moderate intensity load power between the anaerobic barrier and the peak power accurately, and cooperate with various auxiliary sports, mental and psychological aspects, the combination of labor and rest, sleep management, no smoking and limiting alcohol, Health eating habits and optimizing medicine were the overall plan. The patients' blood pressure before and after exercise, monitoring blood pressure and electrocardiogram (ECG) were measured every day, 5 days a week, 5 days a week for a total of 12 weeks, the patients' blood pressure was measured before and after exercise, and the blood pressure and electrocardiogram were continuously monitored during exercise. Heart rate and oxygen saturation were adjusted according to the degree of blood pressure stability. The changes of blood pressure before, after and at 1th week were compared and analyzed. Results: patients with hypertension took at least one antihypertensive drug before exercise treatment. Systolic blood pressure pressure (SBP) [125 鹵11mm Hg before exercise and 116 鹵10mm Hg after exercise], diastolic blood pressure pressure (DBP) [74 鹵8mm Hg before exercise and 71 鹵7mm Hg after exercise] were significantly lower than those before exercise (125 鹵11mm Hg and 116 鹵10mm Hg after exercise) [74 鹵8mm Hg before exercise and 71 鹵7mm Hg after exercise]. Stop antihypertensive drugs for more than 6 weeks. Resting SBP before exercise was still significantly lower than that at week 1 (drug use) [1 week (127 鹵8 mm Hg) and 12 week (121 鹵9 mm Hg)] P 0.05A, and after 1 week and 12 weeks of exercise, there was no significant difference in resting DBP before and after exercise (P 0.05). Conclusion: this study shows that there is no significant difference in resting DBP before and after exercise. Conclusion: this study shows that there is no significant difference between the rest DBP before and after exercise. Conclusion: this study shows that there is no significant difference between the rest DBP before and after exercise. Using CPET objective quantitative evaluation to guide the accurate formulation of individual moderate intensity exercise as the core of the overall plan, Can make the hypertension patient obtain the astonishing effect of lowering blood pressure, And it can still maintain blood pressure stability after withdrawal, which is worthy of further study. Objective: to monitor the stroke blood pressure during cardiopulmonary exercise testing in cardiopulmonary exercise test (cardiopulmonary exercise testing) by non-invasive method, and to compare it with the traditional cuff intermittent blood pressure measurement. The maximum blood pressure during cardiopulmonary exercise test was observed in order to find out whether the quantitative blood pressure could be used as the indication of termination of cardiopulmonary exercise test. Methods: six healthy volunteers who underwent CPET in Fuwei Hospital from 2016 to October were selected. In the routine cardiopulmonary exercise test, a continuous noninvasive blood pressure monitoring instrument was worn. The values of intermittent cuff blood pressure and continuous stroke blood pressure in different stages were analyzed statistically. Results: during the cardiopulmonary exercise test, 6 records were performed. Two of the patients had the highest hypertension over 250 mmHg, while the most hypertension detected by cuff intermittent manometry was 187mm Hg.There was a significant difference in systolic blood pressure between warm up period and 5 minute recovery period (p 0.05), but there was no statistical difference in other periods. Diastolic blood pressure (DBP) was significantly different in 2 minutes of recovery period and 5 minutes of recovery period, but there was no statistical difference in other periods. Conclusion: continuous stroke blood pressure can better reflect the continuous state and limit value of blood pressure in CPET. No specific maximum blood pressure can be used as a reference for termination of cardiopulmonary exercise test.
【學(xué)位授予單位】:北京協(xié)和醫(yī)學(xué)院
【學(xué)位級(jí)別】:碩士
【學(xué)位授予年份】:2017
【分類號(hào)】:R544.1

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