本文關(guān)鍵詞： OXL 穩(wěn)定型心絞痛 經(jīng)皮冠狀動脈介入治療 預(yù)后　出處：《中國醫(yī)科大學(xué)學(xué)報》2017年07期 　論文類型：期刊論文

【摘要】：目的觀察穩(wěn)定型心絞痛患者經(jīng)皮冠狀動脈介入治療(PCI)術(shù)后血漿OX40L水平的變化趨勢,并探討其與患者預(yù)后的關(guān)系。方法選取穩(wěn)定型心絞痛患者200例,均行PCI,測定術(shù)前及術(shù)后不同時間點血漿OX40L的濃度,觀察血漿OX40L濃度的變化趨勢。對所有患者進(jìn)行18個月的隨訪,隨訪終點為不良心血管事件。結(jié)果患者PCI術(shù)后血漿OX40L濃度較術(shù)前明顯升高(P0.05),術(shù)后24 h達(dá)峰值。185例患者隨訪成功,其中發(fā)生不良心血管事件(事件組)患者39例(21.08%),無心血管事件(無事件組)患者146例(78.92%)。事件組血漿OX40L峰值水平高于無事件組[分別為(37.51±6.17)和(30.95±3.81)pg/m L],差異有統(tǒng)計學(xué)意義(P0.05)。logistic回歸分析顯示,OX40L峰值與患者隨訪期間發(fā)生不良心血管事件密切相關(guān)(P0.05)。結(jié)論PCI術(shù)增加穩(wěn)定型心絞痛患者OX40L的表達(dá),峰值水平對術(shù)后18個月不良心血管事件有良好預(yù)測價值。
[Abstract]:Objective to observe the change trend of plasma OX40L level in patients with stable angina pectoris after percutaneous coronary intervention (PCI). Methods 200 patients with stable angina pectoris were selected and their plasma OX40L levels were measured before and after operation. The change trend of plasma OX40L concentration was observed. All patients were followed up for 18 months. Results the plasma OX40L concentration in patients with PCI was significantly higher than that before operation (P 0.05), and the peak value at 24 hours after operation was .185 cases were followed up successfully. There were 39 patients with adverse cardiovascular events (event group). The peak level of plasma OX40L in the event group was higher than that in the no event group. [It was 37.51 鹵6.17) and 30.95 鹵3.81g / mL, respectively. The difference was statistically significant (P 0.05). Logistic regression analysis showed. The peak value of OX40L was closely related to adverse cardiovascular events during follow-up. Conclusion PCI can increase the expression of OX40L in patients with stable angina pectoris. Peak level is a good predictor of adverse cardiovascular events 18 months after operation.
【作者單位】： 沈陽醫(yī)學(xué)院附屬第二醫(yī)院心內(nèi)科;
【基金】：沈陽市科技計劃(F13-220-9-39/F14-158-9-26) 沈陽醫(yī)學(xué)院青年基金(20122037)
【分類號】：R541.4
【正文快照】： 經(jīng)皮冠狀動脈介入治療(percutaneous coronaryintervention,PCI)目前是冠心病患者治療的重要措施之一,能顯著改善預(yù)后。但術(shù)后支架內(nèi)再狹窄、支架內(nèi)血栓形成、缺血事件再發(fā)等仍時有發(fā)生,這與PCI術(shù)加重局部炎癥反應(yīng)、介導(dǎo)心肌及血管損傷密切相關(guān)。研究[1]表明,OX40及其配體(OX4

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本文編號：1480734