本文關(guān)鍵詞： 心電圖 放療 化療 乳腺癌 高血壓　出處：《暨南大學(xué)學(xué)報(bào)(自然科學(xué)與醫(yī)學(xué)版)》2017年04期 　論文類型：期刊論文

【摘要】：目的:探討心電圖早期評(píng)價(jià)高血壓腫瘤患者接受聯(lián)合放、化療后心臟功能改變的臨床價(jià)值.方法:分析符合WHO/ISH高血壓診斷標(biāo)準(zhǔn)的高血壓左側(cè)乳腺癌術(shù)后患者60例為觀察組,無(wú)高血壓左側(cè)乳腺癌術(shù)后患者30例為對(duì)照組,血壓水平均經(jīng)正規(guī)治療嚴(yán)格控制,年齡35~70歲.兩組均接受心肌酶譜和心電圖檢查,比較兩組心肌酶譜,心電圖和超聲心動(dòng)圖診斷的差異.結(jié)果:化療前觀察組肌酸激酶同工酶-MB(CK-MB)和肌酸激酶(CK)水平與對(duì)照組無(wú)明顯差異(P0.05),化療期中后期觀察組肌酸激酶同工酶-MB(CK-MB)和肌酸激酶(CK)水平明顯升高,升高程度大于對(duì)照組(P0.05);觀察組新增異常超聲心動(dòng)圖比率(28.3%)顯著高于對(duì)照組(13.3%)(P0.05);觀察組化療后新增異常心電圖比率(36.7%)顯著高于對(duì)照組(23.3%)(P0.05),心電圖和超聲心動(dòng)圖比較顯示超聲心動(dòng)圖異�；颊叨鄶�(shù)有心電圖異常,其中觀察組100%,對(duì)照組83.3%.結(jié)論:經(jīng)胸放療聯(lián)合化療明顯地導(dǎo)致高血壓患者心功能異常,心電圖能準(zhǔn)確地預(yù)測(cè)經(jīng)胸放療聯(lián)合化療患者心功能異常,為后續(xù)診療提供依據(jù).
[Abstract]:Objective: to explore the early evaluation of electrocardiogram (ECG) in patients with hypertensive tumor receiving combined radiotherapy. Clinical value of cardiac function changes after chemotherapy. Methods: 60 patients with left breast cancer who met the diagnostic criteria of WHO/ISH hypertension were analyzed as observation group. Thirty patients with left breast cancer without hypertension were taken as control group. The blood pressure level was strictly controlled by regular treatment, aged 35 ~ 70 years. Both groups were examined by myocardial enzyme spectrum and electrocardiogram (ECG), and the myocardial enzyme spectrum was compared between the two groups. Results: before chemotherapy, the levels of creatine kinase isoenzyme (CK-MBK) and creatine kinase (CK) in the observation group were not significantly different from those in the control group (P 0.05). The levels of creatine kinase isoenzyme (CK-MBK) and creatine kinase (CK) in the observation group were significantly higher than those in the control group (P 0.05). The ratio of newly added abnormal echocardiography in the observation group was significantly higher than that in the control group (P 0.05). The rate of new abnormal ECG in the observation group was significantly higher than that in the control group (P 0.05). The comparison of ECG and echocardiography showed that most of the patients with abnormal echocardiography had abnormal ECG, among which the observation group was 100%. Conclusion: transthoracic radiotherapy combined with chemotherapy can obviously lead to abnormal cardiac function in patients with hypertension. Electrocardiogram can accurately predict cardiac dysfunction in patients with transthoracic radiotherapy combined with chemotherapy. To provide basis for follow-up diagnosis and treatment.
【作者單位】： 廣州醫(yī)科大學(xué)附屬腫瘤醫(yī)院心電圖;廣州醫(yī)科大學(xué)附屬腫瘤醫(yī)院超聲影像科;廣州醫(yī)科大學(xué)附屬腫瘤醫(yī)院胸外乳腺科;
【基金】：廣東省科技廳項(xiàng)目(粵科規(guī)財(cái)字2015-110號(hào))
【分類號(hào)】：R540.41;R544.1
【正文快照】： 含蒽環(huán)類抗癌藥的化療和放射治療在乳腺癌的綜合治療中占有重要的地位,對(duì)早期乳腺癌的乳房保留及提高乳腺癌的局部控制率和生存率起了重要作用,但二者都會(huì)造成心肌損傷,近年來(lái),由于腫瘤放、化療聯(lián)合治療的廣泛應(yīng)用,所致心臟損傷也明顯增加[1-3].心臟是高血壓病最常受損傷的靶

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