目的：肝硬化（hepatic cirrhosis）是各種慢性肝病發(fā)展的晚期階段,是各種因素長(zhǎng)期反復(fù)作用導(dǎo)致了肝細(xì)胞損傷,并引起肝星狀細(xì)胞的活化,同時(shí)氧化應(yīng)激以及多種細(xì)胞因子也參與了本病的發(fā)生發(fā)展過(guò)程。門(mén)靜脈高壓癥（portal hypertension,PHT）是肝硬化失代償期主要的臨床表現(xiàn)之一,其引起的主要并發(fā)癥食管胃底靜脈曲張破裂出血嚴(yán)重威脅著患者的生命。血紅素氧合酶（heme oxygenase, HO）是血紅素代謝途徑中的起始酶和限速酶,共有3種亞型,其中HO-1活性最高,廣泛分布于全身組織,可被多種引起細(xì)胞氧化應(yīng)激的損傷因素所誘導(dǎo),HO-1及其催化產(chǎn)物膽綠素（biliverdin）、膽紅素（biliubin）和CO（carbon monoxide,CO）在體內(nèi)均有顯著的抗炎、抗細(xì)胞增殖及調(diào)節(jié)細(xì)胞因子表達(dá)等重要作用。目前,奧曲肽（octreotide, OCT）作為臨床上常用藥物治療食管胃底靜脈曲張破裂出血,但奧曲肽在門(mén)脈高壓階段的作用機(jī)制尚不完全清楚。本研究觀察奧曲肽降低門(mén)脈高壓的作用是否調(diào)控了HO-CO系統(tǒng),以探討奧曲肽降門(mén)脈高壓的可能機(jī)制,并進(jìn)一步證實(shí)HO-CO系統(tǒng)在肝硬... 

【文章來(lái)源】：大連醫(yī)科大學(xué)遼寧省

【文章頁(yè)數(shù)】：40 頁(yè)

【學(xué)位級(jí)別】：碩士

【部分圖文】：

肝硬化門(mén)脈高壓組大鼠有大量腹水形成

【參考文獻(xiàn)】：
期刊論文
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