發(fā)布時(shí)間：2021-07-07 16:01

　　研究背景:目前全世界有近50%人口感染了幽門(mén)螺桿菌（Helicobacter pylori,H.pylori）,我國(guó)H.pylori感染率達(dá)50%。已證明H.pylori感染可導(dǎo)致包含慢性胃炎、消化性潰瘍、胃癌和胃粘膜相關(guān)組織淋巴瘤在內(nèi)的多種消化系統(tǒng)疾病;同時(shí)H.pylori感染也與不明原因的缺鐵性貧血、代謝綜合征、心腦血管疾病、免疫性血小板減少性紫癜等胃腸外疾病相關(guān)。根除H.pylori可延緩慢性萎縮性胃炎的發(fā)展,降低早期胃癌患者異時(shí)性胃癌的發(fā)生率,或可有效減輕我國(guó)胃癌疾病負(fù)擔(dān)。全球范圍內(nèi)H.pylori根除失敗現(xiàn)象越來(lái)越普遍,其主要原因包括H.pylori對(duì)抗生素耐藥率逐漸升高,患者對(duì)根除治療方案依從性不佳,臨床用藥方案不規(guī)范等;反復(fù)的根除治療失敗繼而加劇了補(bǔ)救根除治療的困難,造成部分H.pylori感染遷延難治。有學(xué)者提出患者接受共識(shí)推薦的四聯(lián)方案根除治療失敗3次及以上考慮為難治性幽門(mén)螺桿菌感染。針對(duì)難治性幽門(mén)螺桿菌感染,目前指南和共識(shí)尚缺乏推薦的根除治療方案。研究目的:本研究旨在探求14天改良序貫療法對(duì)難治性幽門(mén)螺桿菌感染的根除療效,分析其難治性幽門(mén)螺桿菌抗生素耐藥性特點(diǎn),并結(jié)... 

【文章來(lái)源】：山東大學(xué)山東省 211工程院校 985工程院校 教育部直屬院校

【文章頁(yè)數(shù)】：46 頁(yè)

【學(xué)位級(jí)別】：碩士

【文章目錄】：
中文摘要
Abstract
符號(hào)說(shuō)明
研究背景
研究對(duì)象與方法
研究結(jié)果
討論
結(jié)論
附錄
參考文獻(xiàn)
幽門(mén)螺桿菌與胃腸外疾病
    參考文獻(xiàn)
致謝
學(xué)位論文評(píng)閱及答辯情況表


【參考文獻(xiàn)】：
期刊論文
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[2]Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication: A prospective single-center study from China[J]. Chun-Hua Wang,Sheng-Tao Liao,Jun Yang,Chun-Xia Li,Ying-Ying Yang,Ran Han,Dong-Feng Chen,Chun-Hui Lan.  World Journal of Gastroenterology. 2015(39)
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