研究背景自從1983年澳大利亞學(xué)者Warren和Marshall首次從慢性活動性胃炎患者的胃粘膜活檢組織中分離出幽門螺桿菌（Helicobacter pylori, Hp）以來,關(guān)于Hp的研究引起廣泛關(guān)注。1989年,Krajden等首次從胃炎患者的牙菌斑（1/29,3.45%）中分離出Hp,并推測口腔有可能是Hp在人體內(nèi)除胃以外的重要聚集地。1993年,Ferguson等從9位Hp胃炎患者的唾液中培養(yǎng)出1例（1/9,11.11%）具有活力的Hp。此后國內(nèi)外許多學(xué)者進(jìn)行了口腔中Hp的檢測,大量的研究報道表明,患有慢性胃炎、消化性潰瘍等疾病患者的牙菌斑、牙周組織和唾液中存在Hp,其形態(tài)學(xué)、生化特性和免疫特性均與胃粘膜Hp相似,對同一個患者的胃內(nèi)Hp和口腔內(nèi)Hp進(jìn)行基因分型,也發(fā)現(xiàn)其具有顯著的同源性。此后,口腔Hp檢測、口腔Hp與胃Hp感染的相關(guān)性,以及與胃部各種疾病的關(guān)系成為研究熱點(diǎn)。目的研究唾液幽門螺桿菌抗原測試板（HPS）,在檢測Hp感染中的臨床價值,及探討影響胃Hp根除成功率的因素。方法（1）選擇因上消化道癥狀初診的成年患者120例,同時接受HPS、14C-尿素呼氣試驗(yàn)（14C-U... 

【文章來源】：浙江大學(xué)浙江省 211工程院校 985工程院校 教育部直屬院校

【文章頁數(shù)】：56 頁

【學(xué)位級別】：碩士

【部分圖文】：

唾液測試板結(jié)構(gòu)示意圖

圖3HPS檢測試板，圖中顯示檢測結(jié)果陽性2.3.1.2特點(diǎn)HPs檢測的是有毒的幽門螺桿菌(攜帶CagA基因)所釋放的尿素酶，與普通螺旋桿菌釋放的尿素酶空間構(gòu)象不同。見圖4、s[l’】。

2.3.1.2特點(diǎn)HPs檢測的是有毒的幽門螺桿菌(攜帶CagA基因)所釋放的尿素酶，與普通螺旋桿菌釋放的尿素酶空間構(gòu)象不同。見圖4、s[l’】。圖4毒性強(qiáng)的Hp釋放的尿素酶圖5普通Hp釋放的尿素酶

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