Despite the availability of an effective vaccine, hepatitis B virus（HBV） infection remains a major health problem, with more than 350 million chronically infected people worldwide and over 1 million annual deaths due to cirrhosis and liver cancer. HBV mutations are primarily generated due both to a lack of proofreading capacity by HBV polymerase and to host immune pressure, which is a very important factor for predicting disease progression and therapeutic outcomes. Several types of HBV precore/... 

【文章來源】：World Journal of Gastroenterology. 2016年17期 第4287-4296頁

【文章頁數(shù)】：10 頁

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