【摘要】：目的:觀察二甲雙胍治療2型糖尿病(T2DM)合并非酒精性脂肪肝病(NAFLD)的療效和安全性。方法:106例T2DM合并NAFLD患者隨機均分為對照組和觀察組。對照組患者接受T2DM合并NAFLD的健康教育,并給予生活干預(yù)治療(糖尿病飲食、運動治療);觀察組患者在對照組治療的基礎(chǔ)上給予二甲雙胍片0.5 g,口服,每日3次。兩組患者療程均為12周。觀察兩組患者的臨床療效,治療前后肝臟脂肪含量、體質(zhì)量指數(shù)(BMI)、空腹血糖(FPG)、穩(wěn)態(tài)胰島素評價指數(shù)(HOMA-IR)、甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、糖化血紅蛋白(Hb A1c)及不良反應(yīng)發(fā)生情況。結(jié)果:治療后,兩組患者肝臟脂肪含量、上述指標(除對照組HOMA-IR外)均顯著優(yōu)于同組治療前,且觀察組優(yōu)于對照組,差異均有統(tǒng)計學意義(P0.05)。觀察組患者總有效率顯著高于對照組,差異有統(tǒng)計學意義(P0.05)。兩組患者治療期間均未見明顯不良反應(yīng)發(fā)生。結(jié)論 :在常規(guī)治療的基礎(chǔ)上,二甲雙胍治療T2DM合并NAFLD的療效和安全性均較好。
[Abstract]:Objective: to observe the efficacy and safety of metformin in the treatment of type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD). Methods: 106 patients with T2DM complicated with NAFLD were randomly divided into control group and observation group. The patients in the control group received health education of T2DM combined with NAFLD and were given life intervention therapy (diabetic diet, exercise therapy), while the patients in the observation group were given metformin tablets 0.5g, oral three times a day, on the basis of treatment in the control group. The course of treatment in both groups was 12 weeks. The clinical efficacy, liver fat content, body mass index (BMI), fasting blood glucose (FPG), steady insulin evaluation index (HOMA-IR), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glycosylated hemoglobin (Hb A1c) and adverse reactions were observed before and after treatment. Results: after treatment, the liver fat content of the two groups (except the control group HOMA-IR) was significantly better than that of the same group before treatment, and the observation group was better than the control group, the difference was statistically significant (P 0.05). The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P 0.05). There were no obvious adverse reactions during treatment in both groups. Conclusion: metformin is effective and safe in the treatment of T2DM complicated with NAFLD on the basis of routine treatment.
【作者單位】： 解放軍第117醫(yī)院內(nèi)分泌科;
【分類號】：R587.1;R575.5

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1 戴夢昭;;維格列汀聯(lián)用二甲雙胍治療2型糖尿病療效和安全性的Meta分析[J];中國全科醫(yī)學;2013年29期

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1 崔一U，

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