【摘要】：目的探討超聲造影聯(lián)合常規(guī)血清學(xué)標(biāo)志物評(píng)估失代償期肝硬化患者門靜脈高壓的可行性。方法根據(jù)肝靜脈壓力梯度(hepatic venous pressure gradient,HVPG)將54例失代償期肝硬化門靜脈高壓患者分為HVPG12 mmHg(1 mmHg=0.133 kPa)和HVPG≥12 mmHg兩組。對(duì)血常規(guī)、肝功能、出凝血功能、Childpugh評(píng)分(Child-pugh score,CPS)及肝臟超聲造影定量參數(shù),包括肝動(dòng)脈到達(dá)時(shí)間(hepatic artery arrival time,HAAT)、肝靜脈到達(dá)時(shí)間(hepatic vein arrival time,HVAT)、門靜脈到達(dá)時(shí)間(portal vein arrival time,PVAT)、肝動(dòng)脈-肝靜脈渡越時(shí)間(hepatic artery to hepatic vein arrive transmit time,HA-HVTT)、門靜脈-肝靜脈渡越時(shí)間(portal vein to hepatic vein arrive transmit time,PV-HVTT),進(jìn)行單因素分析和Logistic回歸分析,篩選出可以診斷門靜脈高壓的無(wú)創(chuàng)指標(biāo),并在此基礎(chǔ)上構(gòu)建診斷模型。通過(guò)ROC曲線評(píng)價(jià)模型的診斷價(jià)值并確定界值。結(jié)果建立診斷模型Y=-0.217×PV-HVTT+1.526×CPS-7.097。當(dāng)模型的預(yù)測(cè)概率值≥0.631時(shí),其判斷HVPG≥12 mmHg的敏感性為87.5%,特異性為78.6%,ROC曲線下面積為0.857。結(jié)論由PV-HVTT和CPS建立的無(wú)創(chuàng)診斷模型對(duì)評(píng)估門靜脈高壓有一定的臨床價(jià)值。
[Abstract]:Objective to investigate the feasibility of contrast-enhanced ultrasound combined with routine serological markers in evaluating portal hypertension in patients with decompensated liver cirrhosis. Methods according to hepatic venous pressure gradient (hepatic venous pressure gradient,HVPG), 54 patients with decompensated cirrhotic portal hypertension were divided into HVPG12 mmHg (1 mmHg=0.133 kPa) and HVPG 鈮，

本文編號(hào)：2501066