烏魯木齊市體檢人群非酒精性脂肪肝危險因素的研究
發(fā)布時間：2019-04-09 07:11
【摘要】：近年來,隨著人們生活水平的不斷提高,生活方式和飲食結(jié)構(gòu)的變化,超聲等影像技術(shù)的廣泛應用,非酒精性脂肪性肝病(Nonalcoholic fatty liver disease, NAFLD)患病率逐年上升,其發(fā)病率僅次于病毒性肝炎,已成為發(fā)達國家第一大慢性肝病以及肝功能異常的首要病因。NAFLD發(fā)生與代謝綜合征(MS)、Ⅱ型糖尿病、轉(zhuǎn)氨酶異常、高齡、肝炎病毒感染史等密切相關(guān),并與多種不良行為或嗜好關(guān)系密切。NAFLD患病率在不同生活習性的人群中亦有不同。NAFLD目前主要以預防為主,尚缺乏有效的治療方法。新疆為多民族聚集區(qū),不同民族具有其獨特的遺傳特性和生活行為方式。本研究旨在探討烏魯木齊市體檢人群中不同民族NAFLD的患病情況,并進行危險因素的分析,為今后社區(qū)綜合干預提供科學的理論依據(jù)。目的：期望通過本研究了解烏魯木齊市體檢人群中非酒精性脂肪肝的患病情況,并探討少數(shù)民族地區(qū)非酒精性脂肪肝的危險因素,為采取針對性的預防和治療措施提供科學理論依據(jù)。方法：對2013年1月～6月期間烏魯木齊市某醫(yī)院體檢中心的體檢人群進行流行病學調(diào)查,采用問卷調(diào)查、體格檢查、生化檢查、超聲檢查及心電圖檢查等測量結(jié)果,進行單因素分析及多因素非條件Logistic回歸模型,并計算各研究因素與NAFLD的關(guān)聯(lián)強度OR值及其95%可信區(qū)間,以P0.05差異有統(tǒng)計學意義。結(jié)果：調(diào)查烏魯木齊市體檢人群2503例,診斷NAFLD 490例,其中漢族387例,維吾爾族69例,回族25例,其他9例。有家族史者152例,有既往史者121例。單因素分析：男性非酒精性脂肪肝的患病率高于女性(x2＝15.89,P＝-0.000);不同族別NAFLD患病率有差異(x2=10.094,P=0.000)；有既往史者的NAFLD患病率較高(x2=13.49,P=0.000)；而是否有家族史與NAFLD患病率無關(guān)(x2=3.050,P＝0.087)。對研究對象進行身高、體重及體質(zhì)指數(shù)(BMI)的比較發(fā)現(xiàn),兩組間身高差異有統(tǒng)計學意義(P0.05)；NAFLD組體重及體質(zhì)指數(shù)明顯高于非NAFLD組,差異有統(tǒng)計學意義(P0.05)；且兩組體質(zhì)指數(shù)分級結(jié)果顯示,非NAFLD組人群為超重,而NAFLD組人群為肥胖,此差異有統(tǒng)計學意義(P0.05)。對研究對象的腰圍、臀圍及腰臀比進行比較發(fā)現(xiàn),NAFLD組腰圍及臀圍明顯大于非NAFLD組,且差異均有統(tǒng)計學意義(P0.05)；對腰臀比進行的比較未見統(tǒng)計學差異(P0.05)。多因素非條件Logistic回歸分析發(fā)現(xiàn),將單因素分析有統(tǒng)計學意義的12個變量(性別、年齡、家族史、既往史、身高、體重、空腹血糖等)帶入Logistic回歸模型,采用向前似然比法進行逐步多因素非條件Logistic回歸分析。結(jié)果顯示,年齡大、性別為男性、族別為漢族、有既往史、BMI增大、腰圍增大均為非酒精性脂肪肝的危險因素。結(jié)論：1.烏魯木齊市體檢人群中NAFLD的患病率為19.58%。男性及女性的NAFLD患病率隨著年齡增長而逐漸增高,不同性別、不同年齡的NAFLD患病率有統(tǒng)計學意義；2.超重、肥胖、既往史及族別與非酒精性脂肪肝的發(fā)病關(guān)系密切,腰臀圍大、體重過重是誘發(fā)NAFLID的危險因素。應采取有效干預措施、科學控制體重、合理膳食、加強戶外運動,積極治療糖尿病、高血壓、肝炎等代謝性疾病是降低人群非酒精性脂肪肝患病率的重要措施。
[Abstract]:In recent years, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing year by year with the increasing of people's living standard, and the prevalence of non-alcoholic fatty liver disease (NAFLD) is second only to viral hepatitis. Has become the first major chronic liver disease in developed countries and the primary cause of liver function abnormality. NAFLD is closely related to metabolic syndrome (MS), type II diabetes, abnormal transaminases, advanced age, and hepatitis virus infection, and is closely related to many bad behaviors or hobbies. The prevalence of NAFLD is also different among the population with different life habits. NAFLD is mainly focused on prevention first and lacks effective treatment methods. Xinjiang is a multi-ethnic group, and different peoples have their unique genetic characteristics and lifestyle behavior. The purpose of this study is to explore the prevalence of NAFLD in different ethnic groups in the physical examination population in Urumqi, and to analyze the risk factors and provide a scientific basis for the comprehensive intervention of the community in the future. Objective: To study the prevalence of non-alcoholic fatty liver in the physical examination of Urumqi, and to explore the risk factors of nonalcoholic fatty liver in ethnic minority areas, and to provide scientific basis for the prevention and treatment of non-alcoholic fatty liver. Methods: The epidemiological investigation of the physical examination population of a hospital in the city of Urumqi from January to June 2013 was carried out. The results of questionnaire, physical examination, biochemical examination, ultrasonic examination and electrocardiogram examination were used. A single factor analysis and a multi-factor non-conditional logistic regression model were performed, and the correlation intensity OR value of each study factor and the NAFLD and the 95% confidence interval were calculated. Results: There were 2503 cases of physical examination in Urumqi and 490 cases of NAFLD, of which 387 were Han,69 in Uygur,25 in the Hui and 9 in the other. There were 152 patients with family history and 121 patients with a history of history. Single factor analysis: The prevalence of non-alcoholic fatty liver in male was higher than that of female (x2 = 15.89, P =-0.000); the prevalence of NAFLD in different races was different (x2 = 10.094, P = 0.000); the prevalence of NAFLD with prior history was higher (x2 = 13.49, P = 0.000); and whether family history was independent of the prevalence of NAFLD (x2 = 3.050, P錛，
本文編號：2454956
[Abstract]:In recent years, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing year by year with the increasing of people's living standard, and the prevalence of non-alcoholic fatty liver disease (NAFLD) is second only to viral hepatitis. Has become the first major chronic liver disease in developed countries and the primary cause of liver function abnormality. NAFLD is closely related to metabolic syndrome (MS), type II diabetes, abnormal transaminases, advanced age, and hepatitis virus infection, and is closely related to many bad behaviors or hobbies. The prevalence of NAFLD is also different among the population with different life habits. NAFLD is mainly focused on prevention first and lacks effective treatment methods. Xinjiang is a multi-ethnic group, and different peoples have their unique genetic characteristics and lifestyle behavior. The purpose of this study is to explore the prevalence of NAFLD in different ethnic groups in the physical examination population in Urumqi, and to analyze the risk factors and provide a scientific basis for the comprehensive intervention of the community in the future. Objective: To study the prevalence of non-alcoholic fatty liver in the physical examination of Urumqi, and to explore the risk factors of nonalcoholic fatty liver in ethnic minority areas, and to provide scientific basis for the prevention and treatment of non-alcoholic fatty liver. Methods: The epidemiological investigation of the physical examination population of a hospital in the city of Urumqi from January to June 2013 was carried out. The results of questionnaire, physical examination, biochemical examination, ultrasonic examination and electrocardiogram examination were used. A single factor analysis and a multi-factor non-conditional logistic regression model were performed, and the correlation intensity OR value of each study factor and the NAFLD and the 95% confidence interval were calculated. Results: There were 2503 cases of physical examination in Urumqi and 490 cases of NAFLD, of which 387 were Han,69 in Uygur,25 in the Hui and 9 in the other. There were 152 patients with family history and 121 patients with a history of history. Single factor analysis: The prevalence of non-alcoholic fatty liver in male was higher than that of female (x2 = 15.89, P =-0.000); the prevalence of NAFLD in different races was different (x2 = 10.094, P = 0.000); the prevalence of NAFLD with prior history was higher (x2 = 13.49, P = 0.000); and whether family history was independent of the prevalence of NAFLD (x2 = 3.050, P錛，
本文編號：2454956
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