廣西肝癌高發(fā)區(qū)乙型肝炎病毒基因型分析
[Abstract]:Objective: to investigate the distribution of hepatitis B virus (HBV) genotypes in high incidence areas of liver cancer in Guangxi. Methods: according to sex and age, 103 members of high incidence family (trial group) and 103 members of non-cancer family (control group) were collected, all of them were infected with HBV. Type-specific primer nested PCR and sequencing were used to detect genotypes. Results: a total of 4 genotypes of B / C and D were detected in the two groups. Their proportions in the two groups were 31. 1% and 69. 1% and 30. 1%, 55. 3% and 6. 8%, respectively. There was no significant difference (P0.05). HBeAg positive rate of genotype C was higher than genotype B (P0.05), there was no significant difference in sex, age, national, HBV DNA level (P0.05). Conclusion: in the high incidence region of liver cancer in Guangxi, HBV is dominated by B / C genotype, with a small number of B / C mixed genotype and D genotype. The high incidence of liver cancer in Guangxi is not related to genotype.
【作者單位】: 廣西醫(yī)科大學(xué)第一附屬醫(yī)院感染性疾病科;桂林醫(yī)學(xué)院附屬醫(yī)院消化內(nèi)科;
【基金】:國(guó)家自然科學(xué)基金項(xiàng)目(編號(hào):30960170) 廣西教育廳重點(diǎn)課題(編號(hào):桂教201202ZD021)
【分類號(hào)】:R512.62;R735.7
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