【摘要】：目的分析圍絕經(jīng)期女性胃食管反流病(GERD)的臨床特點(diǎn),提高對(duì)該期女性GERD的認(rèn)識(shí)。方法對(duì)該院2014年1月至2015年12月門診及住院確診GERD的246例患者的臨床資料、胃鏡檢查及24h食管阻抗-pH監(jiān)測結(jié)果進(jìn)行回顧性分析;按性別將患者分為女性組和男性組,根據(jù)月經(jīng)情況又將女性組分為圍絕經(jīng)期組和非圍絕經(jīng)組2個(gè)亞組,對(duì)比分析各組患者的臨床特點(diǎn)。結(jié)果女性組NERD所占比例較男性組高,以非典型癥狀為主訴的發(fā)生率也高于男性組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);女性組中圍絕經(jīng)期組、非圍絕經(jīng)組反酸發(fā)生率均低于男性組(P0.05);圍絕經(jīng)期組弱酸反流次數(shù)與非圍絕經(jīng)組和男性組比較差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論圍絕經(jīng)期女性GERD多以非典型癥狀為主要表現(xiàn),內(nèi)鏡、24h食管阻抗-pH聯(lián)合監(jiān)測是診斷圍絕經(jīng)期女性GERD的選擇。
[Abstract]:Objective to analyze the clinical features of (GERD) in perimenopausal women with gastroesophageal reflux disease (GERD) and to improve the understanding of GERD. Methods from January 2014 to December 2015, the clinical data, gastroscopy and 24-hour esophageal impedance (pH) monitoring of 246 patients with GERD were retrospectively analyzed. The patients were divided into female group and male group according to gender, and female group was divided into two subgroups according to menstrual condition, peri-menopausal group and non-perimenopausal group. The clinical characteristics of each group were compared and analyzed. Results the proportion of NERD in female group was higher than that in male group, and the incidence of atypical symptoms was higher than that in male group (P0.05). The incidence of acid regurgitation in female group and non-menopausal group was lower than that in male group (P0.05), and the frequency of weak acid reflux in peri-menopausal group was significantly higher than that in non-menopausal group and male group (P0.05). Conclusion atypical symptoms are the main manifestation of GERD in perimenopausal women. Endoscopy and 24 h esophageal impedance-pH combined monitoring are the choice of diagnosis of GERD in perimenopausal women.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第二醫(yī)院消化內(nèi)科;
【基金】：國家自然科學(xué)青年基金項(xiàng)目(81101827)
【分類號(hào)】：R571

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