【摘要】：目的探討中老年慢性胃病患者幽門螺桿菌(Hp)感染與不同胃病、胃黏膜病理改變之間的關(guān)系。方法對(duì)631例50歲以上的慢性胃病患者行胃鏡、病理活檢和~(13)C-尿素呼氣試驗(yàn)(~(13)C-UBT),觀察不同年齡組、不同胃病組Hp感染情況,觀察胃黏膜不同病理組織學(xué)改變情況。結(jié)果中老年慢性胃病患者HP感染率為61.17%。50~59歲、60~69歲、70~79歲、≥80歲組Hp感染率分別為64.26%、64.44%、58.42%、48.28%;慢性淺表性胃炎、慢性萎縮性胃炎、胃潰瘍、十二指腸潰瘍和胃癌(GC)Hp感染率分別為41.38%、60.08%、72.19%、74.23%和36.84%,消化性潰瘍Hp感染率最高;胃黏膜炎癥、腸上皮化生、低級(jí)別上皮內(nèi)瘤變、高級(jí)別上皮內(nèi)瘤變、GC的Hp感染率分別為52.43%、76.62%、55.04%、47.62%、36.84%,腸上皮化生組Hp感染率明顯高于其他組,隨著病變程度加深Hp感染率逐漸下降。結(jié)論中老年慢性胃病與HP感染密切相關(guān),隨著年齡增長,HP感染率呈下降趨勢(shì)。HP感染在胃黏膜炎癥、腸上皮化生、不典型增生、GC病理學(xué)改變、進(jìn)展中起促進(jìn)作用,應(yīng)早期根除Hp。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (Hp) infection and pathological changes of gastric mucosa in middle-aged and aged patients with chronic gastric disease. Methods 631 patients over 50 years old with chronic gastropathy underwent gastroscopy, pathological biopsy and ~ (13) C-urea breath test (~ (13) C-UBT). The infection of Hp was observed in different age groups and different gastric diseases groups. The histopathological changes of gastric mucosa were observed. Results the infection rate of HP in the middle-aged and elderly patients with chronic gastric disease was 61.17. 59 years old, 60 ~ 69 years old, 70 ~ 79 years old, and 鈮，

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