【摘要】：背景:狼瘡相關(guān)性胰腺炎在臨床較為少見,但其病情復(fù)雜、預(yù)后欠佳,在臨床診療過程中容易發(fā)生漏診和誤診,目前,關(guān)于此病的認(rèn)識(shí)大多來源于病案報(bào)道及小樣本回顧研究,對(duì)于該病的發(fā)病機(jī)理、臨床表現(xiàn)及治療方法也缺乏共識(shí),該病對(duì)于全身器官及系統(tǒng)的損害使其成為多學(xué)科治療的難題。目的:通過綜述目前對(duì)狼瘡性胰腺炎的相關(guān)臨床研究進(jìn)展,從而為臨床醫(yī)生更好的認(rèn)識(shí)及治療此疾病提供參考及幫助。方法:全面檢索發(fā)表在中國期刊全文數(shù)據(jù)庫、中國優(yōu)秀碩士、博士學(xué)位論文數(shù)據(jù)、中國重要會(huì)議論文全文數(shù)據(jù)庫、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫、中國知網(wǎng)數(shù)據(jù)庫、中國萬方數(shù)據(jù)庫、中國維普數(shù)據(jù)庫、PubMed、Medline、Ovid、Embase、Cochrane Library數(shù)據(jù)庫有關(guān)系統(tǒng)性紅斑狼瘡與胰腺炎臨床研究進(jìn)展的所有中英文文獻(xiàn),并總結(jié)該疾病的相關(guān)臨床研究進(jìn)展。結(jié)果與結(jié)論:狼瘡相關(guān)性胰腺炎是一種與狼瘡活動(dòng)密切相關(guān)的胰腺炎癥性病變,雖然該病的年發(fā)病率僅為0.4—1.1‰,但其死亡率卻高達(dá)37%,其中重癥患者高達(dá)75%。狼瘡性胰腺炎的病情復(fù)雜,無明顯特異性臨床表現(xiàn),故一經(jīng)診斷需早期干預(yù),如出現(xiàn)胰腺出血壞死、多器官受累、嚴(yán)重感染等情況時(shí),往往提示預(yù)后不良,更需嚴(yán)密監(jiān)測,積極治療,早期給予中至大量的激素及免疫抑制劑對(duì)于狼瘡性胰腺炎是安全有效的,其并非是狼瘡性胰腺炎的主要病因,亦不會(huì)加重病情,反而有利于病情緩解,改善預(yù)后。
[Abstract]:Background: lupus associated pancreatitis is rare in clinical practice, but its condition is complex and its prognosis is poor. It is easy to miss diagnosis and misdiagnosis in the course of clinical diagnosis and treatment. At present, most of the knowledge about this disease comes from medical record report and small sample retrospective study. There is a lack of consensus on the pathogenesis, clinical manifestations and treatment of the disease, and the damage to the whole body organs and systems makes it a difficult problem for multidisciplinary treatment. Objective: to review the clinical research progress of lupus pancreatitis so as to provide reference and help for clinicians to better understand and treat this disease. Methods: a comprehensive search was made for the data published in the full text database of Chinese journals, the excellent master's degree, the doctoral degree thesis, the full text database of important conference papers in China, the Chinese biomedical literature database and the China knowledge network database. All the Chinese and English literatures on the progress of clinical research on systemic lupus erythematosus and pancreatitis were reviewed in China Wanfang Database, China Wiper Database and PubMed,Medline,Ovid,Embase,Cochrane Library Database, and the related clinical research progress of this disease was summarized. Results & conclusion: lupus associated pancreatitis is a kind of pancreatic inflammatory disease closely related to lupus activity. Although the annual incidence of lupus is only 0.4-1.1 鈥，

本文編號(hào)：2344334