【摘要】：目的觀察腹水濃縮回輸聯(lián)合腹腔內注藥治療肝硬化難治性腹水的效果,并探討其機制。方法 60例肝硬化難治性腹水患者隨機分為觀察組和對照組各30例,分別予腹水濃縮回輸聯(lián)合腹腔內注藥和單純腹水濃縮回輸治療,比較兩組療效及24 h尿量,檢測兩組治療前后血清膽紅素(TBil)、ALT、AST、血氨(NH3)、白蛋白(ALB),采用ELISA法檢測兩組血清腎素、醛固酮及血管緊張素Ⅱ。結果觀察組總有效率高于對照組(P0.05);治療后觀察組血清TBi L低于對照組,ALB和24 h尿量均高于對照組(P均0.05);觀察組腎素、醛固酮和血管緊張素Ⅱ明顯低于對照組(P均0.05)。其余指示差異無統(tǒng)計學意義。結論腹水濃縮回輸聯(lián)合腹腔內注藥治療肝硬化難治性腹水療效較好,其作用機制可能與抑制腎素-血管緊張素-醛固酮系統(tǒng)有關。
[Abstract]:Objective to observe the effect of concentrated ascites infusion combined with intraperitoneal injection in the treatment of refractory ascites of liver cirrhosis and its mechanism. Methods 60 patients with refractory ascites of liver cirrhosis were randomly divided into observation group (n = 30) and control group (n = 30). Serum bilirubin (TBil), ALT,AST, serum ammonia (NH3) was detected before and after treatment, albumin (ALB), was used to detect serum renin, aldosterone and angiotensin 鈪，

本文編號：2340693