【摘要】：目的探討抗焦慮抑郁藥物對慢傳輸性便秘(STC)伴焦慮抑郁障礙患者肛門直腸動力和感覺的影響及其可能機(jī)制,為STC的規(guī)范化綜合治療提供臨床幫助。方法選擇STC病例128例,予HAMD評分,87例評分≥8分界定為STC伴焦慮抑郁障礙。隨機(jī)分為對照組(42例)、抗焦慮抑郁藥物研究組(45例),對照組予乳果糖口服液10 ml,每天3次,8周,研究組相同劑量乳果糖口服液的同時予帕羅西汀20 mg/d,8周。兩組分別于治療前、治療后8周實施肛門直腸動力和感覺的檢測。結(jié)果兩組均未發(fā)生嚴(yán)重不良反應(yīng),研究組有2例于6~7周間失訪;兩組治療前肛門直腸動力和感覺功能各指標(biāo)間差異無統(tǒng)計學(xué)意義;治療組治療前后相比,肛門括約肌壓力有所提高(P0.05),直腸最低敏感量、直腸最大耐受量、直腸最大順應(yīng)性均有顯著下降(P0.01),但直腸靜息壓、縮窄壓、模擬大便括約肌凈減壓差異無統(tǒng)計學(xué)意義(P0.05);兩組治療后8周相比,治療組肛門括約肌壓力、直腸最大耐受量較對照組改變有顯著性差異(P0.05),直腸最低敏感量、直腸最大順應(yīng)性較對照組下降更顯著(P0.01),直腸靜息壓、縮窄壓、模擬大便括約肌凈減壓差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論有必要將焦慮抑郁的評價列入到STC患者常規(guī)診療過程中;對于伴有情緒障礙者應(yīng)及時予抗焦慮抑郁藥物的干預(yù),從而打斷情緒障礙與肛門直腸動力和感覺障礙之間的惡性循環(huán)。
[Abstract]:Objective to investigate the effects of antianxiety and depression drugs on anorectal motility and sensation in patients with slow transit constipation (STC) with anxiety and depression disorder and to provide clinical help for standardized comprehensive treatment of STC. Methods 128 patients with STC were assessed with HAMD and 87 patients with STC with anxiety and depression were classified as STC with score 鈮，

本文編號：2335747