【摘要】：目的探討鈣衛(wèi)蛋白(FC)水平與潰瘍性結(jié)腸炎(UC)腸道病變嚴重程度、病變范圍之間的關(guān)系。方法 UC患者納入后行結(jié)腸鏡檢查、抽血及留取糞便標本檢測鈣衛(wèi)蛋白。參照UC內(nèi)鏡嚴重程度指數(shù)(UCEIS)對5個結(jié)腸腸段進行內(nèi)鏡評分,為評價FC水平與病變嚴重程度、病變范圍之間的關(guān)系,應(yīng)用Spearman相關(guān)性分析FC與最高內(nèi)鏡評分(M-UCEIS)、總內(nèi)鏡評分(S-UCEIS)之間關(guān)系。結(jié)果共有64例UC完成82次結(jié)腸鏡檢查及FC檢測。FC水平與M-UCEIS明顯相關(guān)(r=0.794,P0.01)。應(yīng)用ROC曲線分析,鑒別內(nèi)鏡病變中重度的最佳界值510.6 mg/kg,敏感度和特異度分別為71.4%和100.0%。與M-UCEIS相比,FC水平與S-UCEIS強相關(guān)(r=0.821,P0.01)。結(jié)論 FC水平與UC腸道黏膜病變范圍、病變嚴重程度相關(guān),可作為結(jié)腸鏡的非侵入性替代方法。
[Abstract]:Objective to investigate the relationship between the level of calcitonin (FC) and the severity and extent of (UC) intestinal lesions in ulcerative colitis. Methods the patients with UC were examined by colonoscopy, blood samples and fecal samples were collected for calcitonin. According to UC endoscopic severity index (UCEIS), five colon segments were evaluated by endoscopy to evaluate the relationship between FC level and severity and extent of lesion. The relationship between FC and maximum Endoscopic score (M-UCEIS) and Total Endoscopic score (S-UCEIS) was analyzed by Spearman correlation analysis. Results A total of 64 patients with UC underwent 82 colonoscopy and FC examination. The level of FC was significantly correlated with M-UCEIS (r = 0.794, P 0.01). By ROC curve analysis, the optimal threshold value of 510.6 mg / kg was obtained for the differential diagnosis of moderate and severe endoscopic lesions. The sensitivity and specificity were 71.4% and 100.0%, respectively. Compared with M-UCEIS, FC level was strongly correlated with S-UCEIS (r = 0.821, P 0.01). Conclusion FC level is correlated with the extent and severity of UC intestinal mucosal lesions, and can be used as a noninvasive alternative to colonoscopy.
【作者單位】： 深圳市南山區(qū)人民醫(yī)院消化內(nèi)科;深圳市南山區(qū)人民醫(yī)院中心實驗室;
【基金】：深圳市南山區(qū)科技創(chuàng)新局資助項目(編號:南科研衛(wèi)2013020號)
【分類號】：R574.62

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